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leucine rich pentatricopeptide repeat containing

Summary

Gene Symbol

LRPPRC

Organism

Homo sapiens (human)

External Links

NCBI Gene

10128

KEGG Gene ID

PubChem

10128

Alliance of Genome Resources

HGNC:15714

Annotation

Keyword

3D-structure
Acetylation
Autophagy
DNA-binding
Direct protein sequencing
Disease variant
Leigh syndrome
Membrane
Mitochondrion
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
Transcription regulation
Transit peptide
Transport
mRNA transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E5KNY5	130 kDa leucine-rich protein
P42704	130 kDa leucine-rich protein GP130

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
mitochondrial RNA catabolic process
negative regulation of mitochondrial RNA catabolic process	IEA
autophagy
regulation of gene expression	IEA
mitochondrion transport along microtubule	TAS

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

metabolic process [inference]

catabolic process [inference]

autophagy

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mitochondrial RNA catabolic process

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mitochondrial RNA catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

mitochondrial gene expression [inference]

mitochondrial RNA processing [inference]

mitochondrial mRNA polyadenylation

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mitochondrial RNA catabolic process

macromolecule biosynthetic process [inference]

gene expression [inference]

mitochondrial gene expression [inference]

mitochondrial RNA processing [inference]

mitochondrial mRNA polyadenylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial RNA catabolic process

RNA catabolic process [inference]

mitochondrial RNA catabolic process

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mitochondrial RNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mitochondrial RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial RNA catabolic process

RNA catabolic process [inference]

mitochondrial RNA catabolic process

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mitochondrial RNA catabolic process

RNA processing [inference]

mitochondrial RNA processing [inference]

mitochondrial mRNA polyadenylation

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

process utilizing autophagic mechanism [inference]

autophagy

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

establishment of RNA localization [inference]

RNA transport [inference]

mRNA transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

organelle localization [inference]

mitochondrion localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of catabolic process [inference]

regulation of mitochondrial RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of RNA metabolic process [inference]

regulation of mitochondrial RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of RNA metabolic process [inference]

regulation of mitochondrial RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of mitochondrial mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

negative regulation of mitochondrial mRNA catabolic process

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
condensed nuclear chromosome	IDA
acrosomal vesicle
nucleus	EXP
nucleus	IDA
nucleus	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

cellular anatomical structure [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane [inference]

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome [inference]

nuclear chromosome [inference]

condensed nuclear chromosome

condensed chromosome [inference]

condensed nuclear chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membraneless organelle [inference]

chromosome [inference]

nuclear chromosome [inference]

condensed nuclear chromosome

condensed chromosome [inference]

condensed nuclear chromosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
mRNA 3'-UTR binding	IBA
protein binding	IPI
microtubule binding	TAS
ubiquitin protein ligase binding	IPI
beta-tubulin binding	IDA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding

RNA binding

mRNA binding

mRNA 3'-UTR binding

protein binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

tubulin binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3652	Leigh disease	Alliance of Genome Resources
DOID:0111180	French Canadian Leigh disease	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	72416	MGI:1919666

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements