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phospholipase C gamma 2

Summary

Gene Symbol

PLCG2

Organism

Odobenus rosmarus divergens (Pacific walrus)

External Links

NCBI Gene: 101378505
KEGG Gene ID: oro:101378505
PubChem: 101378505

Annotation

Keyword

Calcium
Hydrolase
Lipid degradation
Phosphoprotein
Reference proteome
Repeat
SH2 domain
SH3 domain
Transducer

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2U3VC63

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphatidylinositol-mediated signaling	IEA	30032202
phospholipid catabolic process	IEA	22301074
positive regulation of epithelial cell migration	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
phosphatidylinositol phospholipase C activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Carnivora

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
phospholipid catabolic process
positive regulation of epithelial cell migration
release of sequestered calcium ion into cytosol

Displaying entries **1 - 10** of 17 in total

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InterPro
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain
C2 domain superfamily
C2 domain
EF-hand domain pair
PH-like domain superfamily
PLC-gamma, C-terminal SH2 domain
PLC-gamma, N-terminal SH2 domain
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
Phosphatidylinositol-specific phospholipase C, X domain

KEGG BRITE Database

Orthology

K05859

Name

phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Ortholog

Displaying entries **31 - 40** of 43 in total

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Species	Gene ID	OrthoDB
Neogale vison	122911198	452646_0:002f37
Leopardus geoffroyi	123577697	46844_0:002e6e
Ursus americanus	123791349	9643_0:0019b3
Mirounga angustirostris	123855225	9716_0:002622
Meles meles	123931254	9662_0:004479
Lynx rufus	124511524	61384_0:001225
Lutra lutra	125089755	9657_0:004b64
Prionailurus viverrinus	125152537	61388_0:003f0b
Panthera uncia	125916347	29064_0:004779
Nyctereutes procyonoides	129497753	34880_0:004331