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FERM, ARH/RhoGEF and pleckstrin domain protein 1

Summary

Gene Symbol

FARP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10160

PubChem

10160

Alliance of Genome Resources

HGNC:3591

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Cytoplasm
Developmental protein
Guanine-nucleotide releasing factor
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Synaptosome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
C9JME2	FERM, RhoGEF and pleckstrin domain-containing protein 1
A0A2X0TVY0	FERM, RhoGEF and pleckstrin domain-containing protein 1
Q9Y4F1	Chondrocyte-derived ezrin-like protein FERM, RhoGEF and pleckstrin domain-containing protein 1 Pleckstrin homology domain-containing family C member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
enzyme-linked receptor protein signaling pathway	IEA
synapse assembly	ISS
Rac protein signal transduction	IEA
dendrite morphogenesis	ISS
retrograde trans-synaptic signaling by trans-synaptic protein complex	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

trans-synaptic signaling by trans-synaptic complex [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

actin filament-based process [inference]

actin cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

trans-synaptic signaling by trans-synaptic complex [inference]

retrograde trans-synaptic signaling by trans-synaptic protein complex

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of presynapse assembly

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of presynapse assembly

regulation of presynapse organization [inference]

regulation of presynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of presynapse assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytosol	ISS
cytosol	TAS
cytoskeleton	IEA
cytoplasmic side of plasma membrane	ISS
filopodium	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

extrinsic component of postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron spine [inference]

dendritic spine

actin-based cell projection [inference]

filopodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

postsynapse [inference]

dendritic spine

Displaying **all 5** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISS
guanyl-nucleotide exchange factor activity	IBA
protein binding	IPI	32296183
cytoskeletal protein binding	IEA
small GTPase binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ferm

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 14 in total

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InterPro
Band 4.1 domain
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
FARP1/FARP2/FRMD7, FERM domain C-lobe
FERM adjacent
FERM central domain
FERM domain
FERM superfamily, second domain
FERM, C-terminal PH-like domain
FERM, N-terminal

Ortholog

Displaying entries **1 - 10** of 93 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10160	Xenbase:XB-GENE-486840
Mus musculus	223254	Xenbase:XB-GENE-486840	MOUSE12757
Caenorhabditis elegans	227377	WB:WBGene00001490
Rattus norvegicus	306183		RATNO10356
Pan troglodytes	452632		PANTR07995
Canis lupus familiaris	476970		CANLF08808
Bos taurus	531927		BOVIN04048
Macaca mulatta	701031		MACMU16454
Monodelphis domestica	100019503		MONDO32760
Equus caballus	100060841		HORSE12929