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MIRAGE
phospholipase C beta 2

Summary
Gene Symbol
  • PLCB2
Organism
Propithecus coquereli (Coquerel's sifaka)
NCBI Gene
105814456
KEGG Gene ID
pcoq:105814456
PubChem
105814456
Annotation
Keyword
  • Calcium
  • Coiled coil
  • Hydrolase
  • Lipid degradation
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Transducer
Proteins
Displaying 1 entry
UniProt Protein Name
A0A2K6FKG8
Annotation information from UniProt.
Gene Ontology (GO)
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Primates
Group Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Functional Category
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
  • V: Defense mechanisms
Displaying all 8 entries
Gene Ontology
calcium ion binding
hydrolase activity
lipid metabolic process
metal ion binding
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol
sensory perception of bitter taste
Displaying entries 1 - 10 of 14 in total
InterPro
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, EF-hand domain
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, catalytic domain
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-beta, PH domain
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
KEGG BRITE Database
Orthology
K05858
Name
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
References
Rhea

RHEA:33179

H2O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
H+ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 72 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
5330 HUMAN22272
18796 MOUSE35892
85240 RATNO26020
453330 PANTR09966
701951 MACMU42738
100031869 MONDO01824
100086536 ORNAN04505
100157641 PIGXX14623
100229635 TAEGU26073
100348672 RABIT06185
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025