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pre-mRNA processing factor 8

Summary

Gene Symbol

PRPF8

Organism

Homo sapiens (human)

External Links

NCBI Gene

10594

PubChem

10594

Alliance of Genome Resources

HGNC:17340

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Retinitis pigmentosa
Ribonucleoprotein
Spliceosome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6P2Q9	220 kDa U5 snRNP-specific protein PRP8 homolog Splicing factor Prp8 p220

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
spliceosomal tri-snRNP complex assembly	IDA	20595234
spliceosomal tri-snRNP complex assembly	IBA
RNA splicing, via transesterification reactions	TAS	9774689
mRNA splicing, via spliceosome	NAS	30975767
mRNA splicing, via spliceosome	IC	11991638

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly [inference]

spliceosomal tri-snRNP complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly [inference]

spliceosomal tri-snRNP complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly [inference]

spliceosomal tri-snRNP complex assembly

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	NAS	30975767
nucleus	IDA	22720776 28781166 29301961
nucleoplasm	TAS
U5 snRNP	IBA
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex [inference]

Sm-like protein family complex [inference]

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex [inference]

U5 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

nuclear protein-containing complex [inference]

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

precatalytic spliceosome [inference]

U2-type precatalytic spliceosome

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex [inference]

U5 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

catalytic complex [inference]

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

ribonucleoprotein complex [inference]

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

precatalytic spliceosome [inference]

U2-type precatalytic spliceosome

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex [inference]

U5 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
protein binding	IPI	16723661 17332742 18951082 20696395 22365833 22720776 23704370 23793891 26711270 27173435 28514442 30021884 32814053 33961781 35271311 39251607 9774689
peptidase activity	IMR	17559875
peptidase activity	IKR	17559875
U6 snRNA binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity [inference]

metal-dependent deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

metal-dependent deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity [inference]

metal-dependent deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

metal-dependent deubiquitinase activity

binding [inference]

protein binding

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding [inference]

K63-linked polyubiquitin modification-dependent protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

snRNA binding [inference]

pre-mRNA binding [inference]

pre-mRNA intronic binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pre-mRNA-processing-splicing factor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
U1 snRNA binding
U2 snRNA binding
U5 snRNA binding
U6 snRNA binding
mRNA processing
metallopeptidase activity
pre-mRNA intronic binding

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InterPro
JAB1/MPN/MOV34 metalloenzyme domain
MPN domain
PRO8NT domain
PROCN domain
PROCT domain
PRP8 domain IV core
Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily
Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
Pre-mRNA-processing-splicing factor 8

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110403	retinitis pigmentosa 13	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10594	Xenbase:XB-GENE-966799
Mus musculus	192159	Xenbase:XB-GENE-966799	MOUSE03264
Rattus norvegicus	287530		RATNO00445
Danio rerio	393951		DANRE08527
Pan troglodytes	468374		PANTR13191
Canis lupus familiaris	480651		CANLF19149
Bos taurus	507371		BOVIN12500
Macaca mulatta	721238		MACMU14570
Monodelphis domestica	100012573		MONDO15900
Equus caballus	100072388		HORSE02951

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OrthoDB (Group)

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Acknowledgements