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centromere protein C

Summary

Gene Symbol

CENPC

Organism

Homo sapiens (human)

External Links

NCBI Gene

1060

PubChem

1060

Alliance of Genome Resources

HGNC:1854

Annotation

Keyword

3D-structure
Alternative splicing
Centromere
Chromosome
DNA-binding
Isopeptide bond
Kinetochore
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q03188	Centromere autoantigen C Centromere protein C 1 Interphase centromere complex protein 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitotic cell cycle	IMP	21529714
spindle attachment to meiosis I kinetochore	IBA
cell division	IEA
chromosome segregation	IMP NAS	21529714 36085283
attachment of mitotic spindle microtubules to kinetochore	IBA

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

chromosome segregation

attachment of spindle microtubules to kinetochore [inference]

attachment of mitotic spindle microtubules to kinetochore

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

meiotic cell cycle process [inference]

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

mitotic cell cycle process [inference]

attachment of mitotic spindle microtubules to kinetochore

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

kinetochore organization [inference]

kinetochore assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

kinetochore assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

kinetochore assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

kinetochore assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

kinetochore assembly

reproductive process [inference]

meiotic cell cycle process [inference]

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
pericentric heterochromatin	IDA	21529714
midbody	IDA
condensed chromosome, centromeric region	IDA	11682612
nucleoplasm	IDA TAS
inner kinetochore	IPI	36085283

GO Hierarchy

cellular component

protein-containing complex [inference]

inner kinetochore

protein-DNA complex [inference]

chromatin [inference]

heterochromatin [inference]

pericentric heterochromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

kinetochore

chromosomal region [inference]

chromosome, centromeric region [inference]

condensed chromosome, centromeric region

supramolecular complex [inference]

kinetochore

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19503796 27881301 30021884 33961781
DNA binding	TAS	1339310
identical protein binding	IPI	19503796
centromeric DNA binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Uncharacterized protein

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
centromeric DNA binding
spindle attachment to meiosis I kinetochore

Displaying **all 4** entries
InterPro
Centromere protein C/Mif2/cnp3
Mif2/CENP-C cupin domain
RmlC-like cupin domain superfamily
RmlC-like jelly roll fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060218	CREST syndrome	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 53 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	100306948		Xenbase:XB-GENE-6452731
Oryctolagus cuniculus	100345012			RABIT05397
Xenopus tropicalis	100379894		Xenbase:XB-GENE-6452278
Pongo abelii	100434744	9601_0:0015f7		PONAB27455
Ailuropoda melanoleuca	100484216			AILME05050
Nomascus leucogenys	100588399			NOMLE37030
Loxodonta africana	100674740			LOXAF08670
Cavia porcellus	100720032			CAVPO21562
Sus scrofa	100737668			PIGXX33746
Cricetulus griseus	100761015			CRIGR21872

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OrthoDB (Group)

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Acknowledgements