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carboxylesterase 1

Summary

Gene Symbol

CES1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1066

PubChem

1066

Alliance of Genome Resources

HGNC:1863

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lipid droplet
Lipid metabolism
Phosphoprotein
Reference proteome
Serine esterase
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P23141	Acyl-coenzyme A:cholesterol acyltransferase Brain carboxylesterase hBr1 Carboxylesterase 1 Cholesteryl ester hydrolase Cocaine carboxylesterase Egasyn HMSE Methylumbelliferyl-acetate deacetylase 1 Monocyte/macrophage serine esterase Retinyl ester hydrolase Serine esterase 1 Triacylglycerol hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IDA	11015575
cholesterol metabolic process	IDA	16024911
response to toxic substance	TAS	1918003
positive regulation of cholesterol efflux	IMP	16971496 18599737 18762277
negative regulation of cholesterol storage	IMP	16971496 18599737 18762277

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

medium-chain fatty acid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to organic cyclic compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to chemical [inference]

response to toxic substance

response to organic substance [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to organic cyclic compound [inference]

response to sterol [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to cholesterol [inference]

cellular response to cholesterol

cellular response to organic cyclic compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to lipid [inference]

response to sterol [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to cholesterol [inference]

cellular response to cholesterol

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to organic cyclic compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

response to alcohol [inference]

response to cholesterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to organic cyclic compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to oxygen-containing compound [inference]

response to sterol [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to cholesterol [inference]

cellular response to cholesterol

response to alcohol [inference]

response to cholesterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to organic cyclic compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

reverse cholesterol transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

reverse cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of bile acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of bile acid biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of bile acid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of bile acid biosynthetic process

regulation of bile acid metabolic process [inference]

regulation of bile acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of bile acid biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of bile acid metabolic process [inference]

regulation of bile acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of steroid biosynthetic process [inference]

regulation of bile acid biosynthetic process

regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of bile acid metabolic process [inference]

regulation of bile acid biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of bile acid biosynthetic process

regulation of localization [inference]

regulation of lipid storage [inference]

regulation of cholesterol storage [inference]

negative regulation of cholesterol storage

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of organic acid transport [inference]

regulation of bile acid secretion

regulation of secretion [inference]

regulation of bile acid secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

negative regulation of biological process [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of cholesterol storage

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of bile acid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of bile acid biosynthetic process

regulation of bile acid metabolic process [inference]

regulation of bile acid biosynthetic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	16024911
endoplasmic reticulum	IDA
endoplasmic reticulum	IBA
endoplasmic reticulum lumen	TAS
lipid droplet	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sterol esterase activity	IDA	11015575 16024911 16971496 18762277
protein binding	IPI	32296183
methylumbelliferyl-acetate deacetylase activity	IEA
carboxylic ester hydrolase activity	IBA
carboxylesterase activity	IDA	18762277 8218228

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

sterol esterase activity

carboxylic ester hydrolase activity

deacetylase activity [inference]

methylumbelliferyl-acetate deacetylase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Carboxylesterase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase type B, active site
Carboxylesterase type B, conserved site
Carboxylesterase, type B

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3119	gastrointestinal system cancer	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 66** of 66 in total

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Species	Gene ID	Orthologous MAtrix
Phascolarctos cinereus	110207510	PHACI21592
Vulpes vulpes	112929624	VULVU24727
Bos indicus x Bos taurus	113876829	BOBOX13005
Bos indicus x Bos taurus	113876830	BOBOX12976
Bos indicus x Bos taurus	113876841	BOBOX13005
Panthera leo	122208807	PANLE29264

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements