GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Carbohydrate metabolism
Cell membrane
Endosome
Glycosidase
Lipid degradation
Lipoprotein
Lysosome
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UQ49	Ganglioside sialidasedis Membrane sialidase N-acetyl-alpha-neuraminidase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glycosphingolipid catabolic process	TAS
carbohydrate metabolic process	IDA	12730204
negative regulation of clathrin-dependent endocytosis	IDA	26251452
oligosaccharide catabolic process	IBA IDA	10861246
positive regulation of epidermal growth factor receptor signaling pathway	IMP	17334392

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
external side of plasma membrane	IEA
recycling endosome membrane	IDA	26251452
plasma membrane	IDA TAS	12730204 26251452
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
exo-alpha-(2->6)-sialidase activity	IEA
exo-alpha-(2->3)-sialidase activity	IDA ISS	11298736 15847605 17334392
exo-alpha-sialidase activity	IBA IDA TAS	10861246
alpha-sialidase activity	IDA	12730204
exo-alpha-(2->8)-sialidase activity	IDA ISS	15847605

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

alpha-sialidase activity

exo-alpha-sialidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000162139

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12357

Name

sialidase-2/3/4 [EC:3.2.1.18]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06147	3.2.1.18	G65889KE	G30207PZ

Disease

Disease Ontology

Displaying entries **1 - 10** of 38 in total

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DO ID	Disease Name	Source
DOID:0050635	alternating hemiplegia of childhood	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:10914	amnestic disorder	DisGeNET DisGeNET
DOID:11037	dissociative amnesia	DisGeNET
DOID:11504	autonomic neuropathy	DisGeNET
DOID:12123	postinflammatory pulmonary fibrosis	DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002094
Gene Name: sialidase 3 (membrane sialidase)

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103187293		CALMI36515
Lepisosteus oculatus	102692266		LEPOC10939
Danio rerio	445250	ZFIN:ZDB-GENE-040801-262	DANRE21263
Danio rerio	780844	ZFIN:ZDB-GENE-061201-39	DANRE21257
Danio rerio	100000684	ZFIN:ZDB-GENE-071220-2	DANRE21294
Danio rerio	555206	ZFIN:ZDB-GENE-061103-511
Danio rerio	793046	ZFIN:ZDB-GENE-071220-1
Astyanax mexicanus	103045559		ASTMX06081
Ictalurus punctatus	108279382		ICTPU11798
Ictalurus punctatus	108280464		ICTPU24295

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements