phosphodiesterase 10A
| UniProt | Protein Name |
|---|---|
| Q9Y233 |
|
| A0A1B1UZQ1 |
|
| A0A1B1UZR0 |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| cAMP catabolic process | ||
| negative regulation of cGMP-mediated signaling | ||
| cAMP-mediated signaling | ||
| negative regulation of cAMP-mediated signaling |
|
|
| cGMP catabolic process |
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol | ||
| perikaryon | ||
| glutamatergic synapse | ||
| extrinsic component of postsynaptic density membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| 3',5'-cyclic-nucleotide phosphodiesterase activity | ||
| 3',5'-cyclic-AMP phosphodiesterase activity | ||
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | ||
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | ||
| cGMP-inhibited cyclic-nucleotide phosphodiesterase activity |
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060998 | striatal degeneration 2 |
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000726 | Dementia |
| HP:0000739 | Anxiety |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001260 | Dysarthria |
| HP:0001268 | Mental deterioration |
| HP:0001270 | Motor delay |
| HP:0001300 | Parkinsonism |
| Disease ID | Disease Name |
|---|---|
| ORPHA:494541 |
|
| OMIM:616921 |
|
| OMIM:616922 |
|
| ORPHA:494526 |
|
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
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Last updated: December 8, 2025