phosphodiesterase 10A
| UniProt | Protein Name |
|---|---|
| Q9Y233 |
|
| A0A1B1UZQ1 |
|
| A0A1B1UZR0 |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| cAMP catabolic process | ||
| negative regulation of cGMP-mediated signaling | ||
| cAMP-mediated signaling | ||
| negative regulation of cAMP-mediated signaling |
|
|
| cGMP catabolic process |
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol | ||
| perikaryon | ||
| glutamatergic synapse | ||
| extrinsic component of postsynaptic density membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| 3',5'-cyclic-nucleotide phosphodiesterase activity | ||
| 3',5'-cyclic-AMP phosphodiesterase activity | ||
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | ||
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | ||
| cGMP-inhibited cyclic-nucleotide phosphodiesterase activity |
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060998 | striatal degeneration 2 |
| HPO ID | HPO Term |
|---|---|
| HP:0001337 | Tremor |
| HP:0002072 | Chorea |
| HP:0002194 | Delayed gross motor development |
| HP:0002307 | Drooling |
| HP:0002310 | Orofacial dyskinesia |
| HP:0002317 | Unsteady gait |
| HP:0002359 | Frequent falls |
| HP:0002487 | Hyperkinetic movements |
| HP:0002548 | Parkinsonism with favorable response to dopaminergic medication |
| HP:0003593 | Infantile onset |
| Disease ID | Disease Name |
|---|---|
| ORPHA:494541 |
|
| OMIM:616921 |
|
| OMIM:616922 |
|
| ORPHA:494526 |
|
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
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Last updated: December 8, 2025