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steroid 5 alpha-reductase 3

Summary

Gene Symbol

SRD5A3

Organism

Rhinopithecus bieti (black snub-nosed monkey)

External Links

NCBI Gene: 108531594
KEGG Gene ID: rbb:108531594
PubChem: 108531594

Annotation

Keyword

Endoplasmic reticulum
NADP
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2K6L2C8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
polyprenol catabolic process	IEA	30032202
dolichol-linked oligosaccharide biosynthetic process	IEA	30032202
dolichol biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K12345

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]

References

20637498

Rhea

a 3-oxo-5α-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.22

PMID

5α-pregnane-3,20-dione + NADP⁺

H⁺ + progesterone + NADPH

Enzyme

1.3.1.22

PMID

17β-hydroxy-5α-androstan-3-one + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.22

PMID

NADP⁺

H⁺ + NADPH

Enzyme

1.3.1.94

PMID

Ortholog

Displaying entries **21 - 30** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gorilla gorilla gorilla	101127484		GORGO30693
Pan paniscus	100987485		PANPA30475
Pan troglodytes	471241		PANTR33958
Pongo abelii	100461714		PONAB27944
Homo sapiens	79644		HUMAN75597
Ursus americanus	123804043		URSAM14626
Ailuropoda melanoleuca	100463734		AILME12634
Mustela putorius furo	101675597		MUSPF03584
Felis catus	101090010		FELCA08252
Panthera leo	122218224		PANLE26976

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024