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ER degradation enhancer, mannosidase alpha-like 2

Summary

Gene Symbol

Edem2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

108687

PubChem

108687

Alliance of Genome Resources

MGI:1915540

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Reference proteome
Signal
Unfolded protein response

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BJT9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum mannose trimming	IBA
positive regulation of retrograde protein transport, ER to cytosol	IDA ISO	24200403

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen
endoplasmic reticulum	IBA ISO
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA
calcium ion binding	IEA
protein binding	IPI	24200403

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **31 - 40** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	111089941		HUMAN56661
Canis lupus familiaris	477209		CANLF09483
Vulpes vulpes	112928221		VULVU22880
Ailuropoda melanoleuca	100482741		AILME15702
Mustela putorius furo	101670584		MUSPF16042
Felis catus	101083162		FELCA07937
Panthera leo	122215621		PANLE02690
Tursiops truncatus	101319758		TURTR14926
Balaenoptera musculus	118881738		BALMU20463
Loxodonta africana	100667220		LOXAF13094

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Last updated: August 19, 2024