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ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 S homeolog

Summary

Gene Symbol

st6gal1.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

108718183

KEGG Gene ID

xla:108718183

PubChem

108718183

Alliance of Genome Resources

Xenbase:XB-GENE-17330217

Annotation

Keyword

Coiled coil
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A974CSL0
A0A1L8G4R6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
sialylation	IEA
protein glycosylation	IEA
protein N-linked glycosylation via asparagine	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

sialylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
Golgi apparatus	IEA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
sialyltransferase activity	IEA
beta-galactoside alpha-2,6-sialyltransferase activity	IEA
transferase activity	IEA
catalytic activity	IEA

GO Hierarchy

molecular function

catalytic activity

transferase activity

glycosyltransferase activity [inference]

sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

KEGG BRITE Database

Orthology

K00778

Name

beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.3.1]

References

2408023

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05990	2.4.3.1	G78059CC	G56749GV

Rhea

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP

Enzyme

2.4.3.1

PMID

2460092

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP

Enzyme

2.4.3.1

PMID

a β-D-galactoside + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.1

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **209** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6480	9606_0:002bee	HGNC:10860
Bos taurus	282073	9913_0:000289
Gallus gallus	396169	9031_0:0024cf
Canis lupus familiaris	478668	9615_0:0042bb
Macaca mulatta	708113	9544_0:00095f
Equus caballus	100059539	9796_0:003bd7
Ornithorhynchus anatinus	100093341	9258_0:00021a
Pongo abelii	100174088	9601_0:0011c6
Taeniopygia guttata	100226346	59729_0:002165
Sus scrofa	100302026	9823_0:003c4a

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024