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ST6 beta-galactoside alpha-2,6-sialyltransferase 1

Summary

Gene Symbol

ST6GAL1

Aliases

CDw75
ST6Gal I

Organism

Homo sapiens (human)

External Links

NCBI Gene

6480

GGDB ID

gg054

HGNC

10860

mRNA

NM_003032

map

3q27-q28

Protein

NP_003023

OMIM

109675

KEGG Gene ID

["hsa:6480"]

PubChem

6480

Alliance of Genome Resources

HGNC:10860

JoGo

ST6GAL1

TogoVar

ST6GAL1

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Phosphoprotein
Proteomics identification
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P15907	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 ST6Gal I Sialyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
N-acetylneuraminate metabolic process	IDA
protein N-linked glycosylation	IDA
protein N-linked glycosylation	IBA
protein N-linked glycosylation	IEA
glycoprotein biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via N-acetylgalactosamine

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via N-acetylgalactosamine

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via N-acetylgalactosamine

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via N-acetylgalactosamine

macromolecule modification [inference]

sialylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via N-acetylgalactosamine

small molecule metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via N-acetylgalactosamine

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via N-acetylgalactosamine

viral process [inference]

viral protein processing

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IDA
extracellular region	ISS
extracellular region	IEA
Golgi apparatus	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

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GO Term	Evidence Code	PMID
beta-galactoside alpha-2,6-sialyltransferase activity	EXP
beta-galactoside alpha-2,6-sialyltransferase activity	TAS
beta-galactoside alpha-2,6-sialyltransferase activity	IDA
beta-galactoside alpha-2,6-sialyltransferase activity	IBA
beta-galactoside alpha-2,6-sialyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000073849

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg054

Gene Symbol

ST6GAL1

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
CMP-Neu5Ac	G84224TW	free	G28868ZC	free	12235148

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
CMP-Neu5Ac	G48558GR	ceramide	12235148
CMP-Neu5Ac	G84224TW	ceramide	12235148
CMP-Neu5Ac	G91237TK	ceramide	12235148
CMP-Neu5Ac	G00031MO	benzyl	12603328
CMP-Neu5Ac	G00056MO	free	12603328

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_671738	NM_147205
Mus musculus	NP_666045	NM_145933

KEGG BRITE Database

Orthology

K00778

Name

beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.3.1]

References

2408023

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05990	2.4.3.1	G78059CC	G56749GV

Rhea

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP

Enzyme

2.4.3.1

PMID

2460092

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.1

PMID

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP

Enzyme

2.4.3.1

PMID

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	445376	ZFIN:ZDB-GENE-060322-3	https://omabrowser.org/oma/info/
Xenopus laevis	108718183	Xenbase:XB-GENE-17330217	https://omabrowser.org/oma/info/
Xenopus laevis	108717116	Xenbase:XB-GENE-6486698	https://omabrowser.org/oma/info/
Xenopus tropicalis	100491268	Xenbase:XB-GENE-983202	https://omabrowser.org/oma/info/
Mus musculus	20440	MGI:108470	https://omabrowser.org/oma/info/
Rattus norvegicus	25197	RGD:3676	https://omabrowser.org/oma/info/
Drosophila melanogaster	37950	FB:FBgn0035050	https://omabrowser.org/oma/info/

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements