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Guidelines

MIRAGE

argininosuccinate lyase

Summary

Gene Symbol

Asl

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

109900

PubChem

109900

Alliance of Genome Resources

MGI:88084

Annotation

Keyword

Acetylation
Arginine biosynthesis
Lyase
Reference proteome
Urea cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91YI0	Arginosuccinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
urea cycle	ISO
urea cycle	IEA
argininosuccinate metabolic process	ISO
liver development	ISO
amino acid metabolic process	IMP	12559843

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

amide metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

urea metabolic process [inference]

urea cycle

amide biosynthetic process [inference]

urea cycle

nitrogen cycle metabolic process [inference]

urea metabolic process [inference]

urea cycle

organonitrogen compound metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

urea metabolic process [inference]

urea cycle

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

primary metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

urea metabolic process [inference]

urea cycle

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

urea metabolic process [inference]

urea cycle

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular nitrogen homeostasis [inference]

nitrogen utilization [inference]

ammonia assimilation cycle

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular nitrogen homeostasis [inference]

nitrogen utilization [inference]

ammonia assimilation cycle

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

nitrogen utilization [inference]

ammonia assimilation cycle

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrial outer membrane	ISO
cytosol	IBA
neuronal cell body	ISO
perikaryon	ISO
perinuclear region of cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body fiber

perikaryon

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
argininosuccinate lyase activity	ISS
argininosuccinate lyase activity	ISO
argininosuccinate lyase activity	IBA
protein binding	IPI	22081021
identical protein binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

argininosuccinate lyase activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lyase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
arginine biosynthetic process via ornithine
argininosuccinate lyase activity
catalytic activity
lyase activity

Displaying **all 7** entries
InterPro
Argininosuccinate lyase, C-terminal
Argininosuccinate lyase
Fumarase/histidase, N-terminal
Fumarate lyase family
Fumarate lyase, N-terminal
Fumarate lyase, conserved site
L-Aspartase-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14755	argininosuccinic aciduria	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ciona intestinalis	100182277		CIOIN05389
Taeniopygia guttata	100222299		TAEGU07557
Taeniopygia guttata	100225196		TAEGU07561
Callithrix jacchus	100388272		CALJA26097
Pongo abelii	100455650		PONAB32396
Ailuropoda melanoleuca	100476336		AILME05999
Sus scrofa	100517757		PIGXX20532
Meleagris gallopavo	100546521		MELGA06962
Loxodonta africana	100664394		LOXAF07671
Cavia porcellus	100720949		CAVPO18925

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Last updated: December 8, 2025