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kinesin family member 2C

Summary

Gene Symbol

KIF2C

Organism

Homo sapiens (human)

External Links

NCBI Gene

11004

PubChem

11004

Alliance of Genome Resources

HGNC:6393

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Centromere
Chromosome
Chromosome partition
Coiled coil
Cytoskeleton
Kinetochore
Microtubule
Mitosis
Motor protein
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A140VKF1
B7Z6Q6
B7Z7M6
Q99661	Kinesin-like protein 6 Mitotic centromere-associated kinesin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
microtubule-based movement	IBA
microtubule depolymerization	TAS	26323690
microtubule depolymerization	IDA	21820309
microtubule depolymerization	IMP	19060894
mitotic metaphase chromosome alignment	IMP	15843429

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

microtubule-based movement

establishment or maintenance of cell polarity [inference]

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

cell cycle process [inference]

attachment of spindle microtubules to kinetochore [inference]

attachment of mitotic spindle microtubules to kinetochore

mitotic cell cycle process [inference]

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

postsynaptic cytoskeleton organization

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

supramolecular fiber organization [inference]

microtubule depolymerization

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of receptor localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of cellular process [inference]

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of chromosome segregation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of biological quality [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
chromosome, centromeric region	IDA	14960279
kinetochore	IDA	14960279 23891108
nucleus	IEA
cytoplasm	IBA
centrosome	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

chromosomal region [inference]

chromosome, centromeric region

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

cytoplasmic microtubule

microtubule end [inference]

microtubule plus-end

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
microtubule motor activity	IBA
protein binding	IPI	11092768 19543227 19632184 21820309 26496610 27173435 33961781 35271311
ATP binding	IEA
microtubule binding	IBA
ATP hydrolysis activity	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

microtubule plus-end binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinesin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain, conserved site
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3796	FB:FBgn0030268
Xenopus tropicalis	11004	Xenbase:XB-GENE-961445
Drosophila melanogaster	16563	FB:FBgn0034827
Drosophila melanogaster	73470	FB:FBgn0030268
Mus musculus	73804		MOUSE41147
Rattus norvegicus	171529		RATNO32697
Pan troglodytes	456548		PANTR20907
Canis lupus familiaris	475382		CANLF04092
Bos taurus	533161		BOVIN27089
Macaca mulatta	705381		MACMU25606