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kinesin family member 2C

Summary

Gene Symbol

KIF2C

Organism

Homo sapiens (human)

External Links

NCBI Gene

11004

PubChem

11004

Alliance of Genome Resources

HGNC:6393

JoGo

KIF2C

TogoVar

KIF2C

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Centromere
Chromosome
Chromosome partition
Coiled coil
Cytoskeleton
Kinetochore
Microtubule
Mitosis
Motor protein
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q99661	Kinesin-like protein 6 Mitotic centromere-associated kinesin
A0A140VKF1
B7Z7M6
B7Z6Q6

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
microtubule-based movement	IBA
microtubule depolymerization	TAS	26323690
microtubule depolymerization	IDA	21820309
microtubule depolymerization	IMP	19060894
mitotic metaphase chromosome alignment	IMP	15843429

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

microtubule-based movement

establishment or maintenance of cell polarity [inference]

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

cell cycle process [inference]

attachment of spindle microtubules to kinetochore [inference]

attachment of mitotic spindle microtubules to kinetochore

mitotic cell cycle process [inference]

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

establishment or maintenance of microtubule cytoskeleton polarity

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of microtubule cytoskeleton polarity

postsynaptic cytoskeleton organization

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

supramolecular fiber organization [inference]

microtubule depolymerization

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of receptor localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of cellular process [inference]

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of chromosome segregation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of biological quality [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
chromosome, centromeric region	IDA	14960279
kinetochore	IDA	14960279 23891108
nucleus	IEA
cytoplasm	IBA
centrosome	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

chromosomal region [inference]

chromosome, centromeric region

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

cytoplasmic microtubule

microtubule end [inference]

microtubule plus-end

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
centromeric DNA binding	TAS	9434124
microtubule plus-end binding	IDA	19632184

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

microtubule plus-end binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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