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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
ADAM metallopeptidase with thrombospondin type 1 motif 13
Summary
- Gene Symbol
-
- ADAMTS13
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Blood coagulation
- Calcium
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Repeat
- Secreted
- Signal
- Zinc
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| Q76LX8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein processing | ||
| cellular response to tumor necrosis factor |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular matrix | ||
| endoplasmic reticulum lumen | ||
| extracellular region | ||
| cell surface | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| integrin binding | ||
| zinc ion binding | ||
| metalloendopeptidase activity | ||
| metallopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- uncharacterized protein
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
- X: Mobilome: prophages, transposons
| Gene Ontology |
|---|
| extracellular matrix organization |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080177 | hepatic veno-occlusive disease | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:0080301 | atypical hemolytic-uremic syndrome | |
| DOID:10772 | thrombotic thrombocytopenic purpura | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:13133 | HELLP syndrome | |
| DOID:13580 | cholestasis | |
| DOID:14067 | Plasmodium falciparum malaria | |
| DOID:418 | systemic scleroderma | |
| DOID:5082 | liver cirrhosis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 102554393 | RGD:1311594 | RATNO26680 | ||
| 103239684 | CHLSB02922 | |||
| 103742812 | NANGA11020 | |||
| 104669720 | RHIRO02121 | |||
| 105471867 | MACNE30038 | |||
| 105528703 | MANLE39598 | |||
| 105580513 | CERAT35433 | |||
| 105712188 | AOTNA27044 | |||
| 105826699 | PROCO31725 | |||
| 108265332 | ICTPU29287 |
