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popeye domain cAMP effector 1

Summary

Gene Symbol

POPDC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

11149

PubChem

11149

Alliance of Genome Resources

HGNC:1152

Annotation

Keyword

Cell adhesion
Cell membrane
Developmental protein
Glycoprotein
Limb-girdle muscular dystrophy
Phosphoprotein
Reference proteome
Tight junction
Transmembrane helix
cAMP-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NE79	Popeye domain-containing protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 19 in total

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GO Term	Evidence Code	PMID
regulation of heart rate	IEA
striated muscle cell differentiation	IBA
sinoatrial node cell development	IEA
positive regulation of receptor recycling	ISS
regulation of membrane potential	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

cell-cell adhesion [inference]

epithelial cell-cell adhesion

vesicle-mediated transport

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development [inference]

cardiac pacemaker cell development [inference]

sinoatrial node cell development

cardiac cell development [inference]

cardiac muscle cell development [inference]

cardiac pacemaker cell development [inference]

sinoatrial node cell development

cell motility [inference]

cell migration [inference]

cell migration involved in heart development

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development [inference]

cardiac pacemaker cell development [inference]

sinoatrial node cell development

cardiac cell development [inference]

cardiac muscle cell development [inference]

cardiac pacemaker cell development [inference]

sinoatrial node cell development

animal organ development [inference]

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development [inference]

cardiac pacemaker cell development [inference]

sinoatrial node cell development

cardiac cell development [inference]

cardiac muscle cell development [inference]

cardiac pacemaker cell development [inference]

sinoatrial node cell development

response to stimulus [inference]

response to stress [inference]

response to ischemia

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

organelle localization [inference]

organelle localization by membrane tethering [inference]

vesicle docking

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of signaling [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of signaling [inference]

positive regulation of receptor recycling

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of endocytic recycling

regulation of vesicle-mediated transport [inference]

regulation of endocytic recycling

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of endocytic recycling

regulation of locomotion [inference]

positive regulation of locomotion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of locomotion

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of endocytic recycling

regulation of vesicle-mediated transport [inference]

regulation of endocytic recycling

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of biological quality [inference]

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of GTPase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cell junction	IDA
membrane	IDA NAS	10441744 16188940
cell projection membrane	IEA
sarcolemma	IBA IDA	26642364
lateral plasma membrane	IDA	16188940

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

plasma membrane region [inference]

cell projection membrane

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

lateral plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26642364
structural molecule activity	IDA	16188940
cAMP binding	IBA

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

ion binding [inference]

anion binding [inference]

cAMP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

blood vessel epicardial substance

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cAMP binding
regulation of membrane potential
striated muscle cell differentiation

Displaying **all 2** entries
InterPro
Cyclic nucleotide-binding domain superfamily
Popeye protein

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110290	autosomal recessive limb-girdle muscular dystrophy type 2X	Alliance of Genome Resources
DOID:6419	tetralogy of Fallot	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	23828		MGI:1346013	MOUSE00838
Drosophila melanogaster	33083		FB:FBgn0031150
Rattus norvegicus	365603		RGD:1561100	RATNO21560
Xenopus laevis	394408		Xenbase:XB-GENE-6254222
Danio rerio	415107		ZFIN:ZDB-GENE-040624-11	DANRE10223
Pan troglodytes	472204	9598_0:001c04		PANTR38773
Canis lupus familiaris	481944			CANLF03023
Bos taurus	539988			BOVIN35616
Macaca mulatta	696255			MACMU35460
Xenopus laevis	779321		Xenbase:XB-GENE-865066