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ER lipid raft associated 2

Summary

Gene Symbol

ERLIN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

11160

PubChem

11160

Alliance of Genome Resources

HGNC:1356

Annotation

Keyword

Acetylation
Alternative splicing
Cholesterol metabolism
Direct protein sequencing
Disease variant
Endoplasmic reticulum
Glycoprotein
Hereditary spastic paraplegia
Reference proteome
Signal
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O94905	Endoplasmic reticulum lipid raft-associated protein 2 Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
A0A384ME54	Endoplasmic reticulum lipid raft-associated protein Stomatin-prohibitin-flotillin-HflC/K domain-containing protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process	IEA
negative regulation of fatty acid biosynthetic process	IMP	24217618
regulation of cholesterol biosynthetic process	IDA	24217618
negative regulation of cholesterol biosynthetic process	IMP	24217618
SREBP signaling pathway	IBA IMP	24217618

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to stimulus [inference]

response to stress [inference]

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to sterol depletion [inference]

SREBP signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein-containing complex	IDA	18468998
endoplasmic reticulum membrane	IBA IDA TAS	16835267 19240031
plasma membrane	IDA TAS
membrane raft	IDA NAS	25204797 34572057
endoplasmic reticulum	IDA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19240031 21343306 22119785 30021884 30352685 33961781
cholesterol binding	IBA
ubiquitin protein ligase binding	IPI	24019521

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cholesterol binding
ubiquitin protein ligase binding

Displaying **all 3** entries
InterPro
Band 7 domain
Band 7/SPFH domain superfamily
Erlin1/2

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110771	hereditary spastic paraplegia 18	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178178		WB:WBGene00016592
Mus musculus	244373		MGI:2387215	MOUSE59613
Rattus norvegicus	290823		RGD:1309010	RATNO10963
Xenopus laevis	444675		Xenbase:XB-GENE-6254593
Pan troglodytes	464112	9598_0:0025a8		PANTR42352
Xenopus laevis	495100		Xenbase:XB-GENE-950149
Xenopus tropicalis	549473		Xenbase:XB-GENE-950144
Canis lupus familiaris	607518			CANLF04700
Bos taurus	616278			BOVIN22087
Ornithorhynchus anatinus	100082208			ORNAN22464

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements