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cadherin 1, type 1, E-cadherin (epithelial)

Summary

Gene Symbol

cdh1

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

114424

PubChem

114424

Alliance of Genome Resources

ZFIN:ZDB-GENE-010606-1

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cytoplasm
Endosome
Glycoprotein
Golgi apparatus
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q90Z37	E-cadherin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IBA
gastrulation with mouth forming second	IMP	15162505 15689372 15905076
neuron migration	IMP	16129396
neural tube formation	IMP	15768401
cell-cell adhesion involved in mesendodermal cell migration	IMP	20079641

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cell-cell adhesion involved in ameboidal cell migration [inference]

cell-cell adhesion involved in mesendodermal cell migration

cell-cell adhesion involved in gastrulation

cell-cell adhesion involved in mesendodermal cell migration

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

cell migration involved in gastrulation

cell division [inference]

embryonic cleavage

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

cell-cell junction organization [inference]

cell-cell junction assembly

adherens junction organization

adherens junction maintenance

cell-cell junction maintenance [inference]

adherens junction maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

embryonic morphogenesis [inference]

gastrulation [inference]

gastrulation with mouth forming second

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet [inference]

epiboly [inference]

epiboly involved in gastrulation with mouth forming second

convergent extension [inference]

convergent extension involved in gastrulation

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

epithelial tube formation [inference]

embryonic epithelial tube formation [inference]

neural tube formation

anatomical structure development [inference]

tissue development [inference]

ectoderm development

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
endosome	IEA
Golgi apparatus	IEA
plasma membrane	IDA	19278297 19911055

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

cytoplasm

cell cortex

membrane

plasma membrane

cell junction [inference]

anchoring junction

cell-cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
G-protein alpha-subunit binding	IPI	19307601
calcium ion binding	IEA
beta-catenin binding	IBA
cadherin binding	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 6** entries
InterPro
Cadherin conserved site
Cadherin, Y-type LIR-motif
Cadherin-like superfamily
Cadherin-like
Cadherin
Catenin binding domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
plasma membrane	PMID:18364700 PMID:19278297 PMID:19911055
Golgi apparatus	PMID:19609345

Ortholog

Displaying entries **1 - 10** of 25 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	999	Xenbase:XB-GENE-482277
Xenopus tropicalis	1001	Xenbase:XB-GENE-482277
Xenopus tropicalis	12550	Xenbase:XB-GENE-12531594
Xenopus tropicalis	12560	Xenbase:XB-GENE-482277
Xenopus tropicalis	83502	Xenbase:XB-GENE-482277
Xenopus tropicalis	114424	Xenbase:XB-GENE-12531594
Xenopus tropicalis	394290	Xenbase:XB-GENE-482277
Xenopus tropicalis	100337618	Xenbase:XB-GENE-12531594
Takifugu rubripes	101071407		TAKRU39532
Astyanax mexicanus	103023785		ASTMX21318

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements