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OMA1 zinc metallopeptidase

Summary

Gene Symbol

OMA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

115209

PubChem

115209

Alliance of Genome Resources

HGNC:29661

Annotation

Keyword

Alternative splicing
Autocatalytic cleavage
Disulfide bond
Lipid-binding
Metal-binding
Metalloprotease
Mitochondrion inner membrane
Reference proteome
Transit peptide
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96E52	Metalloprotease-related protein 1 Overlapping with the m-AAA protease 1 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	ISS
positive regulation of cold-induced thermogenesis	ISS	22433842
energy homeostasis	ISS
protein autoprocessing	ISS
protein quality control for misfolded or incompletely synthesized proteins	IBA IMP	20038677

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein maturation [inference]

protein processing [inference]

adaptive thermogenesis [inference]

diet induced thermogenesis

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

cellular component assembly [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

membrane organization [inference]

mitochondrial membrane organization [inference]

inner mitochondrial membrane organization [inference]

cristae formation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

integrated stress response signaling

HRI-mediated signaling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

negative regulation of developmental process [inference]

negative regulation of mitochondrial fusion

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of mitochondrion organization [inference]

regulation of mitochondrial fusion [inference]

negative regulation of mitochondrial fusion

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of cristae formation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial fusion

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IBA IDA TAS	32132707
mitochondrial membrane	IDA	20038677
mitochondrial intermembrane space	IDA	32132706 32132707

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA IDA IMP	20038677 25275009 32132706 32132707
lipid binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

lipid binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **21 - 30** of 81 in total

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Species	Gene ID	Orthologous MAtrix
Mandrillus leucophaeus	105534917	MANLE01765
Gorilla gorilla gorilla	101143884	GORGO20402
Pan paniscus	100979872	PANPA01489
Pongo abelii	100452274	PONAB17677
Canis lupus familiaris	489569	CANLF15661
Vulpes vulpes	112926095	VULVU20256
Ailuropoda melanoleuca	100484088	AILME14850
Mustela putorius furo	101678232	MUSPF13956
Felis catus	101100067	FELCA19391
Panthera leo	122227362	PANLE10794