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RAS guanyl releasing protein 4

Summary

Gene Symbol

RASGRP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

115727

PubChem

115727

Alliance of Genome Resources

HGNC:18958

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Cytoplasm
Differentiation
Guanine-nucleotide releasing factor
Lipid-binding
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TDF6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
positive regulation of natural killer cell mediated immunity	ISS
phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
Ras protein signal transduction	IBA
myeloid cell differentiation	TAS	11880369
antibacterial innate immune response	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response [inference]

antibacterial innate immune response

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial innate immune response

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

immune response [inference]

innate immune response [inference]

antibacterial innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial innate immune response

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial innate immune response

defense response to other organism [inference]

defense response to bacterium [inference]

antibacterial innate immune response

innate immune response [inference]

antibacterial innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytosol	TAS
cytosol	IDA	11956218
plasma membrane	TAS	11880369
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IDA	11880369
guanyl-nucleotide exchange factor activity	IBA
calcium ion binding	IEA
protein binding	IPI	32296183
zinc ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

diacylglycerol binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

guanine nucleotide exchange factor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
Ras protein signal transduction
calcium ion binding
metal ion binding
small GTPase-mediated signal transduction

Displaying **all 5** entries
InterPro
Ras guanine nucleotide exchange factor domain superfamily
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Ras guanine-nucleotide exchange factors catalytic domain
Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like guanine nucleotide exchange factor

Ortholog

Displaying entries **1 - 10** of 51 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5900	SGD:S000000634
Saccharomyces cerevisiae S288C	5923	SGD:S000000634
Saccharomyces cerevisiae S288C	5924	SGD:S000000634
Saccharomyces cerevisiae S288C	10235	SGD:S000000634
Saccharomyces cerevisiae S288C	19417	SGD:S000000634
Saccharomyces cerevisiae S288C	19418	SGD:S000000634
Xenopus laevis	115727	Xenbase:XB-GENE-17331884
Rattus norvegicus	170668		RATNO18554
Mus musculus	233046		MOUSE54119
Pan troglodytes	468867		PANTR18185