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alkaline phosphatase, liver/bone/kidney

Summary

Gene Symbol

Alpl

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11647

PubChem

11647

Alliance of Genome Resources

MGI:87983

Annotation

Keyword

Biomineralization
Calcium
Cell membrane
Disulfide bond
GPI-anchor
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Signal
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P09242	Alkaline phosphatase 2 Alkaline phosphatase liver/bone/kidney isozyme Phosphoamidase Phosphocreatine phosphatase
Q3TQ02

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
endochondral ossification	IMP	20684022
developmental process involved in reproduction	IGI	17540358
cellular homeostasis	IMP	12082181
cellular homeostasis	IGI	12082181
bone mineralization	IMP	10620060 11028439 12082181 14982838 15920156 20684022 26457330 9056646

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

small molecule metabolic process [inference]

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

organic cyclic compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic hydroxy compound metabolic process [inference]

pyridoxal phosphate metabolic process

futile creatine cycle

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

developmental process [inference]

developmental process involved in reproduction

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development

bone mineralization

tooth mineralization [inference]

cementum mineralization

homeostatic process [inference]

cellular homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organonitrogen compound [inference]

response to vitamin B6

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic cyclic compound

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to cytokine [inference]

response to macrophage colony-stimulating factor

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to inorganic substance [inference]

response to sodium phosphate

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to vitamin B6

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to salt [inference]

response to sodium phosphate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IEA
mitochondrial intermembrane space	IDA	33981039
plasma membrane	ISO
plasma membrane	IDA	10787428 7533563

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

extracellular membrane-bounded organelle

extracellular organelle [inference]

extracellular membrane-bounded organelle

side of membrane

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GO Term	Evidence Code	PMID
alkaline phosphatase activity	ISO	2133555
alkaline phosphatase activity	IDA	10787428 18031938 7533563
alkaline phosphatase activity	IBA
inorganic diphosphate phosphatase activity	IEA
calcium ion binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity

inorganic diphosphate phosphatase activity

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

hydrolase activity, acting on acid phosphorus-nitrogen bonds [inference]

phosphoamidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alkaline phosphatase

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
alkaline phosphatase activity
metal ion binding

Displaying **all 2** entries
InterPro
Alkaline phosphatase
Alkaline-phosphatase-like, core domain superfamily

Rhea

RHEA:12977

H₂O + N-phosphocreatine

phosphate + creatine

Enzyme

3.9.1.1

PMID

RHEA:15017

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110913	adult hypophosphatasia	Alliance of Genome Resources
DOID:0110914	infantile hypophosphatasia	Alliance of Genome Resources
DOID:0110915	childhood hypophosphatasia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	248	SGD:S000002889
Homo sapiens	249	Xenbase:XB-GENE-1010301	HUMAN47927
Saccharomyces cerevisiae S288C	250	SGD:S000002889
Saccharomyces cerevisiae S288C	251	SGD:S000002889
Xenopus tropicalis	11647	Xenbase:XB-GENE-1010301
Saccharomyces cerevisiae S288C	11650	SGD:S000002889
Rattus norvegicus	25586	Xenbase:XB-GENE-1010301	RATNO32949
Xenopus tropicalis	43671	Xenbase:XB-GENE-1010301
Saccharomyces cerevisiae S288C	76768	SGD:S000002889
Bos taurus	280994		BOVIN25254