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LDL receptor related protein associated protein 1

Summary

Gene Symbol

Lrpap1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

116565

PubChem

116565

Alliance of Genome Resources

RGD:620700

Annotation

Keyword

Coiled coil
Direct protein sequencing
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Heparin-binding
Lipoprotein
Phosphoprotein
Receptor
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q99068	Gp330-binding 45 kDa protein Low density lipoprotein receptor-related protein-associated protein 1
A6IK06

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
negative regulation of receptor internalization	ISO
negative regulation of receptor internalization	IBA
signal transduction	ISO
biological_process	ND
negative regulation of very-low-density lipoprotein particle clearance	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

multicellular organismal process [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

amyloid-beta clearance [inference]

amyloid-beta clearance by transcytosis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

amyloid-beta clearance by transcytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of cellular process [inference]

signal transduction

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of receptor-mediated endocytosis

regulation of receptor internalization [inference]

negative regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

negative regulation of amyloid-beta clearance

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
endosome	ISS
endosome	ISO
endosome	IBA
endoplasmic reticulum	ISO
endoplasmic reticulum-Golgi intermediate compartment	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

rough endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10571241
heparin binding	IEA
lipase binding	IBA
lipase binding	IPI	16517593
receptor ligand activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

enzyme binding [inference]

lipase binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

signaling receptor inhibitor activity [inference]

receptor antagonist activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-2-macroglobulin receptor-associated protein

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
heparin binding
lipase binding
low-density lipoprotein particle receptor binding
negative regulation of receptor internalization
negative regulation of very-low-density lipoprotein particle clearance
receptor antagonist activity
very-low-density lipoprotein particle receptor binding

Displaying **all 6** entries
InterPro
Alpha-2-macroglobulin RAP, C-terminal
Alpha-2-macroglobulin RAP, domain 2
Alpha-2-macroglobulin RAP, domain 3
Alpha-2-macroglobulin receptor-associated protein, domain 1
Alpha-2-macroglobulin receptor-associated protein
RAP domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
rough endoplasmic reticulum lumen	PMID:8223699
vesicle	PMID:8223699

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 71 in total

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Species	Gene ID	Orthologous MAtrix
Felis catus	101087737	FELCA09931
Gorilla gorilla gorilla	101151893	GORGO31682
Tursiops truncatus	101327169	TURTR06806
Jaculus jaculus	101597592	JACJA07339
Mustela putorius furo	101676974	MUSPF04879
Heterocephalus glaber	101724769	HETGA26168
Ficedula albicollis	101811968	FICAL02113
Melopsittacus undulatus	101881418	MELUD08202
Chrysemys picta bellii	101949281	CHRPI33710
Ictidomys tridecemlineatus	101964507	ICTTR15473