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G protein-coupled receptor 37

Summary

Gene Symbol

Gpr37

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

117549

PubChem

117549

Alliance of Genome Resources

RGD:619848

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
Endoplasmic reticulum
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Synapse
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IE96
Q9QYC6	G-protein coupled receptor 37 G-protein coupled receptor CNS1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
positive regulation of dopamine metabolic process	ISO
locomotion involved in locomotory behavior	ISO
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA ISO
cellular response to reactive oxygen species	ISO
positive regulation of MAPK cascade	IBA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process [inference]

dopamine biosynthetic process

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process [inference]

dopamine biosynthetic process

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process [inference]

dopamine biosynthetic process

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process [inference]

dopamine biosynthetic process

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process [inference]

dopamine biosynthetic process

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

dopamine metabolic process [inference]

dopamine biosynthetic process

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

dopamine biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendrite development

developmental process [inference]

anatomical structure development [inference]

dendrite development

locomotion [inference]

locomotion involved in locomotory behavior

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of catecholamine metabolic process [inference]

positive regulation of dopamine metabolic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
receptor complex	IBA ISO
endoplasmic reticulum membrane	IEA
plasma membrane	IBA ISO
cell surface	ISO
dendrite	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
neuropeptide binding	ISO
heat shock protein binding	ISO
G protein-coupled peptide receptor activity	IBA ISO
Hsp70 protein binding	ISO
neuropeptide receptor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein domain specific binding [inference]

PDZ domain binding

heat shock protein binding

Hsp70 protein binding

protein-folding chaperone binding [inference]

Hsp70 protein binding

amide binding [inference]

peptide binding

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

neuropeptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity

neuropeptide receptor activity

prosaposin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

G protein-coupled receptor 37 orphan

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
positive regulation of MAPK cascade
prosaposin receptor activity

Displaying **all 3** entries
InterPro
G protein-coupled receptor 37 orphan
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12217	Lewy body dementia	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2861		HGNC:4494	HUMAN91125
Mus musculus	14763	10090_1:001e99	MGI:1313297	MOUSE49679
Canis lupus familiaris	482275			CANLF03604
Bos taurus	532626			BOVIN28361
Danio rerio	568430		ZFIN:ZDB-GENE-041210-264
Macaca mulatta	696628			MACMU33178
Pan troglodytes	738926			PANTR41307
Monodelphis domestica	100017357			MONDO33604
Equus caballus	100071585			HORSE32062
Oryctolagus cuniculus	100356961			RABIT11465

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements