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chloride intracellular channel 1

Summary

Gene Symbol

CLIC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1192

PubChem

1192

Alliance of Genome Resources

HGNC:2062

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Chloride channel
Cytoplasm
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glutathionylation
Nucleus
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q53FB0
Q5SRT3
O00299	Chloride channel ABP Glutaredoxin-like oxidoreductase CLIC1 Glutathione-dependent dehydroascorbate reductase CLIC1 Nuclear chloride ion channel 27 Regulatory nuclear chloride ion channel protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
chloride transport	IDA	9139710
chloride transport	IBA
signal transduction	TAS	16130169
positive regulation of osteoblast differentiation	IEA
regulation of mitochondrial membrane potential	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of cellular process [inference]

signal transduction

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
extracellular space	HDA	22664934
nucleus	TAS	16130169
nucleus	HDA	16791210
nuclear envelope	IDA	9139710
cytoplasm	IDA	10793131

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

nuclear membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cluster of actin-based cell projections [inference]

brush border

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chloride channel activity	IDA	9139710
chloride channel activity	IBA
protein binding	IPI	12163479 12681486 14667819 24338975 26618866 28514442 29924966 31324722 32296183 35156780 36012204
oxidoreductase activity	IEA
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Chloride intracellular channel

Functional Category

C: Energy production and conversion
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
chloride channel activity
chloride transmembrane transport
chloride transport
monoatomic ion transport

Displaying **all 6** entries
InterPro
Glutathione S-transferase, C-terminal domain superfamily
Glutathione S-transferase, C-terminal-like
Glutathione S-transferase, N-terminal
Glutathione transferase family
Intracellular chloride channel
Thioredoxin-like superfamily

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1192	Xenbase:XB-GENE-479419
Mus musculus	114584	Xenbase:XB-GENE-479419	MOUSE20602
Danio rerio	324481		DANRE16440
Rattus norvegicus	406864		RATNO21760
Pan troglodytes	462564		PANTR37732
Canis lupus familiaris	474847		CANLF02563
Bos taurus	515646		BOVIN18769
Oryctolagus cuniculus	100008817		RABIT02204
Monodelphis domestica	100023436		MONDO11048
Ornithorhynchus anatinus	100073413		ORNAN32896