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Guidelines

MIRAGE

tripeptidyl peptidase 1

Summary

Gene Symbol

TPP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1200

PubChem

1200

Alliance of Genome Resources

HGNC:2073

JoGo

TPP1

TogoVar

TPP1

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Lysosome
Metal-binding
Neuronal ceroid lipofuscinosis
Proteomics identification
Reference proteome
Serine protease
Signal
Spinocerebellar ataxia
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O14773	Cell growth-inhibiting gene 1 protein Lysosomal pepstatin-insensitive protease Tripeptidyl aminopeptidase Tripeptidyl-peptidase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
proteolysis	IMP	10965052 9295267
proteolysis	IBA
lipid metabolic process	TAS	9295267
lysosome organization	ISS
nervous system development	IMP	9295267

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

lipid metabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organic substance metabolic process [inference]

lipid metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

developmental process [inference]

anatomical structure development [inference]

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
membrane raft	IDA	17237713
recycling endosome	IDA	17237713
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	IDA	10965052
endopeptidase activity	IMP	10679303
endopeptidase activity	IBA
serine-type endopeptidase activity	IEA
protein binding	IPI	12134079 17237713 19941651 22763445 25544563 32814053

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

amide binding [inference]

peptide binding

ion binding [inference]

anion binding [inference]

lysophosphatidic acid binding

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080059	autosomal recessive spinocerebellar ataxia 7	Alliance of Genome Resources
DOID:0110726	neuronal ceroid lipofuscinosis 2	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026