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tripeptidyl peptidase 1
Summary
- Gene Symbol
-
- TPP1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Autocatalytic cleavage
- Calcium
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Epilepsy
- Glycoprotein
- Lysosome
- Metal-binding
- Neuronal ceroid lipofuscinosis
- Reference proteome
- Serine protease
- Signal
- Spinocerebellar ataxia
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| O14773 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| proteolysis | ||
| lipid metabolic process | ||
| lysosome organization | ||
| nervous system development |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| lysosome | ||
| lysosome | ||
| Golgi apparatus | ||
| melanosome | ||
| lysosomal lumen |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| endopeptidase activity | ||
| endopeptidase activity | ||
| endopeptidase activity | ||
| serine-type endopeptidase activity | ||
| protein binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Tripeptidyl peptidase a
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- P: Inorganic ion transport and metabolism
| Gene Ontology |
|---|
| hydrolase activity |
| metal ion binding |
| proteolysis |
| serine-type endopeptidase activity |
| serine-type peptidase activity |
| tripeptidyl-peptidase activity |
| InterPro |
|---|
| Peptidase S53, activation domain |
| Peptidase S8/S53 domain superfamily |
| Peptidase S8/S53 domain |
| Sedolisin domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080059 | autosomal recessive spinocerebellar ataxia 7 | |
| DOID:0110726 | neuronal ceroid lipofuscinosis 2 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101675115 | MUSPF01008 | ||
| 101707185 | HETGA20430 | ||
| 101867272 | MACFA09604 | ||
| 101951787 | CHRPI26866 | ||
| 101966097 | ICTTR00445 | ||
| 102028524 | CHILA03972 | ||
| 102367029 | LATCH15882 | ||
| 102420099 | MYOLU16268 | ||
| 103167781 | ORNAN15626 | ||
| 103185353 | CALMI31992 |
