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Guidelines

MIRAGE

glycoprotein hormones, alpha subunit

Summary

Gene Symbol

Cga

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12640

PubChem

12640

Alliance of Genome Resources

MGI:88390

Annotation

Keyword

Disulfide bond
Glycoprotein
Hormone
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P01216	Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Follitropin alpha chain Luteinizing hormone alpha chain Lutropin alpha chain Thyroid-stimulating hormone alpha chain Thyrotropin alpha chain
A0A0F7RQH1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
thyroid hormone generation	IMP	12114718
thyroid hormone generation	IBA
G protein-coupled receptor signaling pathway	ISS
G protein-coupled receptor signaling pathway	ISO
gonad development	IMP	12114718

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

gonadotropin secretion [inference]

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development

multicellular organismal process [inference]

organ growth

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development

anatomical structure development [inference]

animal organ development [inference]

gonad development

gland development [inference]

thyroid gland development

reproductive structure development [inference]

gonad development

growth [inference]

developmental growth

organ growth

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

gonadotropin secretion [inference]

secretion [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

gonadotropin secretion [inference]

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

gonadotropin secretion [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

negative regulation of organ growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of developmental growth [inference]

negative regulation of organ growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

negative regulation of organ growth

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

gonadotropin secretion [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

regulation of molecular function [inference]

regulation of signaling receptor activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular space	ISS
extracellular space	ISO
extracellular space	IBA
follicle-stimulating hormone complex	ISS
follicle-stimulating hormone complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

pituitary gonadotropin complex

follicle-stimulating hormone complex

cellular anatomical entity [inference]

extracellular space

Displaying **all 4** entries
GO Term	Evidence Code	PMID
hormone activity	ISO
follicle-stimulating hormone activity	ISS
follicle-stimulating hormone activity	ISO
follicle-stimulating hormone activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

hormone activity

follicle-stimulating hormone activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

follicle-stimulating hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

follicle-stimulating hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glycoprotein hormones alpha chain

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
follicle-stimulating hormone activity
hormone activity
positive regulation of steroid biosynthetic process
thyroid hormone generation

Displaying **all 2** entries
InterPro
Cystine-knot cytokine
Glycoprotein hormone alpha chain

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025