GlyCosmos Portal

Submissions

alcohol dehydrogenase 4 (class II), pi polypeptide

Summary

Gene Symbol

ADH4

Aliases

ADH-2

Organism

Homo sapiens (human)

External Links

NCBI Gene

127

HGNC

252

KEGG Gene ID

hsa:127

PubChem

127

Alliance of Genome Resources

HGNC:252

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Lipid metabolism
Metal-binding
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08319	Alcohol dehydrogenase 2 Alcohol dehydrogenase 4 Alcohol dehydrogenase class II pi chain
V9HVX7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
alcohol metabolic process	IDA	3466164
fatty acid omega-oxidation	IDA	16081420
retinoid metabolic process	IDA	15369820
formaldehyde catabolic process	IBA
ethanol metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

small molecule catabolic process [inference]

organic substance catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular ketone metabolic process [inference]

quinone metabolic process

cellular catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

small molecule metabolic process [inference]

alcohol metabolic process

primary alcohol metabolic process [inference]

alcohol catabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular ketone metabolic process [inference]

quinone metabolic process

small molecule catabolic process [inference]

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular ketone metabolic process [inference]

quinone metabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organic substance catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process

primary alcohol metabolic process [inference]

alcohol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular ketone metabolic process [inference]

quinone metabolic process

cellular catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IBA IDA TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
alditol:NADP+ 1-oxidoreductase activity	IEA
retinol binding	IDA	10407146
zinc ion binding	IBA IDA	10407146
alcohol dehydrogenase activity, zinc-dependent	IBA IDA	10407146
S-(hydroxymethyl)glutathione dehydrogenase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity [inference]

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

NAD-retinol dehydrogenase activity

alcohol dehydrogenase [NAD(P)+] activity [inference]

alcohol dehydrogenase (NAD+) activity

alcohol dehydrogenase activity, zinc-dependent

S-(hydroxymethyl)glutathione dehydrogenase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [inference]

NADPH:quinone reductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

aldehyde dehydrogenase [NAD(P)+] activity [inference]

benzaldehyde dehydrogenase [NAD(P)+] activity

binding [inference]

protein binding

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinal binding [inference]

all-trans retinal binding

retinol binding

small molecule binding [inference]

vitamin binding [inference]

retinal binding [inference]

all-trans retinal binding

retinol binding

alcohol binding [inference]

retinol binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000198099

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K13980

Name

alcohol dehydrogenase 4 [EC:1.1.1.1]

References

1889753

Rhea

RHEA:48488

NAD⁺

H⁺ + NADH

Enzyme

1.1.1.105

PMID

RHEA:21284

all-trans-retinol + NAD⁺

H⁺ + all-trans-retinal + NADH

Enzyme

1.1.1.105

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 54 in total

1

2

3

4

5

6

Next ›

Last »
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	DisGeNET DisGeNET DisGeNET DisGeNET Alliance of Genome Resources
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060119	pharynx cancer	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET
DOID:0060896	Parkinson's disease 23	DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:1107	esophageal carcinoma	DisGeNET DisGeNET DisGeNET
DOID:12351	alcoholic hepatitis	DisGeNET
DOID:14018	alcoholic liver cirrhosis	DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002791
Gene Name: alcohol dehydrogenase 4 (class II), pi polypeptide

Ortholog

Displaying entries **1 - 10** of 58 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178597	WB:WBGene00019240
Drosophila melanogaster	41311	FB:FBgn0011768
Danio rerio	322482	ZFIN:ZDB-GENE-030529-3
Danio rerio	393427	ZFIN:ZDB-GENE-040426-1165
Danio rerio	402841	ZFIN:ZDB-GENE-030529-2
Danio rerio	402939	ZFIN:ZDB-GENE-040426-1910
Xenopus laevis	379488	Xenbase:XB-GENE-17336312
Chrysemys picta bellii	101948797		CHRPI02729
Crocodylus porosus	109322083		CROPO11738
Callithrix jacchus	100394688		CALJA28169

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements