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synaptotagmin 2

Summary

Gene Symbol

SYT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

127833

PubChem

127833

Alliance of Genome Resources

HGNC:11510

Annotation

Keyword

3D-structure
Calcium
Congenital myasthenic syndrome
Cytoplasm
Cytoplasmic vesicle
Differentiation
Disease variant
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N9I0	Synaptotagmin II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
vesicle-mediated transport	IBA
regulation of calcium ion-dependent exocytosis	IBA
cell differentiation	IEA
synaptic vesicle endocytosis
calcium ion-regulated exocytosis of neurotransmitter

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular developmental process [inference]

cell differentiation

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

developmental process [inference]

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

establishment of localization in cell [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

positive regulation of transport [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of transport [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle membrane organization [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
axon	IBA
clathrin-coated endocytic vesicle membrane	TAS
synaptic vesicle membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

exocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

exocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

exocytic vesicle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
SNARE binding	IBA
phosphatidylserine binding
calcium ion binding
protein binding	IPI	17500595 19234194 28514442 32296183 32814053 33961781
calcium-dependent phospholipid binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

small molecule binding [inference]

alcohol binding [inference]

inositol 1,3,4,5 tetrakisphosphate binding

ion binding [inference]

anion binding [inference]

inositol 1,3,4,5 tetrakisphosphate binding

cation binding [inference]

metal ion binding

calcium ion binding

modified amino acid binding [inference]

phosphatidylserine binding

small molecule sensor activity [inference]

metal ion sensor activity [inference]

calcium ion sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

synaptotagmin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
calcium ion binding
calcium ion-regulated exocytosis of neurotransmitter
calcium-dependent phospholipid binding
cellular response to calcium ion
clathrin binding
metal ion binding
phosphatidylserine binding
regulation of calcium ion-dependent exocytosis
regulation of dopamine secretion

Displaying **all 3** entries
InterPro
C2 domain superfamily
C2 domain
Synaptotagmin

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110659	congenital myasthenic syndrome 7	Alliance of Genome Resources
DOID:3635	congenital myasthenic syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6857	FB:FBgn0004242
Drosophila melanogaster	20979	FB:FBgn0004242
Mus musculus	20980	ZFIN:ZDB-GENE-060503-315	MOUSE29598
Rattus norvegicus	24805	ZFIN:ZDB-GENE-060503-315	RATNO06615
Drosophila melanogaster	25716	FB:FBgn0004242
Danio rerio	127833	ZFIN:ZDB-GENE-060503-315
Pan troglodytes	469641		PANTR23387
Macaca mulatta	706962		MACMU24038
Monodelphis domestica	100011843		MONDO14061
Ornithorhynchus anatinus	100077483		ORNAN24642

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements