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coatomer protein complex subunit alpha

Summary

Gene Symbol

Copa

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12847

PubChem

12847

Alliance of Genome Resources

MGI:1334462

Annotation

Keyword

3D-structure
Cytoplasm
Cytoplasmic vesicle
ER-Golgi transport
Golgi apparatus
Hormone
Membrane
Methylation
Phosphoprotein
Protein transport
Reference proteome
Repeat
Secreted
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8CIE6	Alpha-coat protein
Q8BTF0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
pancreatic juice secretion	ISO
endoplasmic reticulum to Golgi vesicle-mediated transport	IBA IEA
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA
intracellular protein transport	IBA IEA
intra-Golgi vesicle-mediated transport	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

cellular localization [inference]

intracellular transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

secretion [inference]

body fluid secretion [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

intracellular transport [inference]

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cellular localization [inference]

intracellular transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

pancreatic juice secretion

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
axon	ISO	21300694
growth cone	IDA ISO	21300694
extracellular space	ISO
cytoplasm	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

vesicle coat [inference]

COPI vesicle coat

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

coated vesicle [inference]

COPI-coated vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

coated vesicle [inference]

COPI-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

coated vesicle [inference]

COPI-coated vesicle

cell body [inference]

neuronal cell body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21300694 36792666
mRNA binding	IDA	21300694
hormone activity	IEA
structural molecule activity	IEA

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

hormone activity

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

coatomer subunit alpha

Functional Category

L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
intra-Golgi vesicle-mediated transport
structural molecule activity

Displaying **all 10** entries
InterPro
Coatomer subunit alpha, WD Associated Region
Coatomer subunit alpha
Coatomer, WD associated region
Coatomer, alpha subunit, C-terminal
Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily
G-protein beta WD-40 repeat
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081242	autoimmune interstitial lung, joint, and kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **122** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1314		HGNC:2230	HUMAN53043
Drosophila melanogaster	38199		FB:FBgn0025725
Caenorhabditis elegans	171860		WB:WBGene00022119
Danio rerio	260439		ZFIN:ZDB-GENE-020905-2	DANRE28844
Rattus norvegicus	304978	10116_1:004049	RGD:1310525	RATNO07596
Pan troglodytes	469552			PANTR22739
Canis lupus familiaris	478973			CANLF14436
Macaca mulatta	719683			MACMU23563
Saccharomyces cerevisiae S288C	851410		SGD:S000002304
Oryctolagus cuniculus	100008878			RABIT03208

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Annotation

OrthoDB (Group)

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Acknowledgements