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alcohol dehydrogenase 5 (class III), chi polypeptide

Summary

Gene Symbol

ADH5

Aliases

ADH-3
ADHX
GSNOR
S-nitrosoglutathione reductase

Organism

Homo sapiens (human)

External Links

NCBI Gene

128

HGNC

253

KEGG Gene ID

hsa:128

PubChem

128

Alliance of Genome Resources

HGNC:253

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Dwarfism
Intellectual disability
Lipid metabolism
Metal-binding
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P11766	Alcohol dehydrogenase 5 Alcohol dehydrogenase class chi chain Alcohol dehydrogenase class-III Glutathione-dependent formaldehyde dehydrogenase S-(hydroxymethyl)glutathione dehydrogenase
Q6IRT1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
response to lipopolysaccharide	IEA
response to redox state	IDA	8460164
fatty acid omega-oxidation	IDA	16081420
retinoid metabolic process	IEA
formaldehyde catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

small molecule catabolic process [inference]

formaldehyde catabolic process

organic substance catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

small molecule catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

organic substance catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular catabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

multicellular organismal process [inference]

system process [inference]

respiratory system process

response to stimulus [inference]

response to stress [inference]

response to nitrosative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to redox state

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

positive regulation of blood pressure

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	IBA TAS
mitochondrion	IEA
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
electron transfer activity		8460164
S-(hydroxymethyl)glutathione dehydrogenase NADP activity	IEA
zinc ion binding	IBA IDA	6375718
S-(hydroxymethyl)glutathione dehydrogenase NAD activity	IEA
alcohol dehydrogenase activity, zinc-dependent	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

alcohol dehydrogenase [NAD(P)+] activity [inference]

alcohol dehydrogenase (NAD+) activity [inference]

alcohol dehydrogenase activity, zinc-dependent

S-(hydroxymethyl)glutathione dehydrogenase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity [inference]

formaldehyde dehydrogenase activity

binding [inference]

protein binding [inference]

identical protein binding

lipid binding [inference]

fatty acid binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000197894

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00121

Name

S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]

References

Rhea

RHEA:19981

NADP⁺ + S-(hydroxymethyl)glutathione

H⁺ + S-formylglutathione + NADPH

Enzyme

1.1.1.284

PMID

RHEA:19985

NAD⁺ + S-(hydroxymethyl)glutathione

H⁺ + S-formylglutathione + NADH

Enzyme

1.1.1.284

PMID

RHEA:10736

a primary alcohol + NAD⁺

H⁺ + an aldehyde + NADH

Enzyme

PMID

RHEA:10740

a secondary alcohol + NAD⁺

H⁺ + a ketone + NADH

Enzyme

1.1.1.1

PMID

RHEA:25290

ethanol + NAD⁺

acetaldehyde + H⁺ + NADH

Enzyme

1.1.1.1

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	DisGeNET DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060119	pharynx cancer	DisGeNET
DOID:0060319	cardiac arrest	DisGeNET
DOID:0060870	isolated growth hormone deficiency	DisGeNET
DOID:0060872	isolated growth hormone deficiency type II	DisGeNET
DOID:0060873	isolated growth hormone deficiency type IA	DisGeNET
DOID:0060874	isolated growth hormone deficiency type IB	DisGeNET
DOID:0060875	isolated growth hormone deficiency type III	DisGeNET
DOID:0080952	AMED syndrome	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0001882	Leukopenia
HP:0001903	Anemia
HP:0002863	Myelodysplasia
HP:0004322	Short stature
HP:0004808	Acute myeloid leukemia
HP:0005301	Persistent left superior vena cava
HP:0005528	Bone marrow hypocellularity
HP:0007018	Attention deficit hyperactivity disorder
HP:0010984	Digenic inheritance

Displaying 1 entry
Disease ID	Disease Name
OMIM:619151	AMED syndrome, digenic

PubChem Disease

MedGen Diseases

AMED syndrome, digenic

OMIM Phenotypes

AMED SYNDROME, DIGENIC; AMEDS

KEGG Diseases

Bone marrow failure syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000519
Gene Name: alcohol dehydrogenase 5 (class III), chi polypeptide

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178597	WB:WBGene00019240
Drosophila melanogaster	41311	FB:FBgn0011768
Ciona intestinalis	445671		CIOIN05226
Callorhinchus milii	103188743		CALMI39805
Callorhinchus milii	121851506		CALMI39805
Latimeria chalumnae	102353852		LATCH02984
Danio rerio	116517	ZFIN:ZDB-GENE-011003-1	DANRE06735
Astyanax mexicanus	103043395		ASTMX03771
Ictalurus punctatus	108269088		ICTPU34772
Electrophorus electricus	113568459		ELEEL49936

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements