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cathepsin B

Summary

Gene Symbol

Ctsb

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13030

PubChem

13030

Alliance of Genome Resources

MGI:88561

Annotation

Keyword

Acetylation
Cell membrane
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Secreted
Signal
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P10605	Cathepsin B1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of catalytic activity	IEA
proteolysis	ISO
cellular response to thyroid hormone stimulus	IEA
collagen catabolic process	IEA ISO
protein catabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

collagen catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

collagen metabolic process [inference]

collagen catabolic process

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein catabolic process

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

decidualization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

regulation of molecular function [inference]

regulation of catalytic activity

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
extracellular space	HDA IBA IDA ISO	12782676 24006456
perinuclear region of cytoplasm	IEA ISO
caveola	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

peptidase inhibitor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane [inference]

sarcolemma

plasma membrane region [inference]

apical plasma membrane

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	IBA IDA ISO	30487519
protein-containing complex binding	ISO
identical protein binding	ISO
endopeptidase activity	IMP ISO	28835281
collagen binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding [inference]

amide binding [inference]

peptide binding

protein-containing complex binding

collagen binding

carbohydrate derivative binding [inference]

proteoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cathepsin B

Functional Category

E: Amino acid transport and metabolism
F: Nucleotide transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
cysteine-type endopeptidase activity
hydrolase activity
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 7** entries
InterPro
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A, propeptide
Peptidase C1A

Disease

Disease Ontology

Displaying entries **11 - 20** of 21 in total

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DO ID	Disease Name	Source
DOID:2671	transitional cell carcinoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:3454	brain infarction	Alliance of Genome Resources
DOID:4914	esophagus adenocarcinoma	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:885	fascioliasis	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **117** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Marmota flaviventris	114085685	93162_0:004736
Podarcis muralis	114594906		PODMU16737
Grammomys surdaster	114613449	491861_0:004bdc
Peromyscus leucopus	114693805	10041_0:005640
Peromyscus leucopus	114703364	10041_0:002a5b
Echeneis naucrates	115040793		ECHNA24151
Salmo trutta	115161960		SALTR57367
Salmo trutta	115172214		SALTR72749
Gadus morhua	115558277		GADMO14223
Sparus aurata	115580670		SPAAU25258