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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
catechol-O-methyltransferase
Summary
- Gene Symbol
-
- COMT
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Catecholamine metabolism
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- Magnesium
- Metal-binding
- Methyltransferase
- Neurotransmitter degradation
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Schizophrenia
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P21964 |
|
| A0A140VJG8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| renal albumin absorption | ||
| norepinephrine secretion | ||
| memory | ||
| synaptic transmission, dopaminergic | ||
| response to salt |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| L-dopa O-methyltransferase activity |
|
|
| orcinol O-methyltransferase activity |
|
|
| protein binding | ||
| catechol O-methyltransferase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14524 | senile degeneration of brain | |
| DOID:14525 | Reye syndrome | |
| DOID:1459 | hypothyroidism | |
| DOID:1470 | major depressive disorder | |
| DOID:150 | disease of mental health | |
| DOID:1509 | avoidant personality disorder | |
| DOID:1520 | colon carcinoma | |
| DOID:1561 | cognitive disorder | |
| DOID:1573 | communicating hydrocephalus | |
| DOID:1574 | alcohol use disorder |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001053 | Hypopigmented skin patches |
| HP:0001061 | Acne |
| HP:0001081 | Cholelithiasis |
| HP:0001136 | Retinal arteriolar tortuosity |
| HP:0001161 | Hand polydactyly |
| HP:0001166 | Arachnodactyly |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0001252 | Hypotonia |
| HP:0001256 | Intellectual disability, mild |
| Disease ID | Disease Name |
|---|---|
| OMIM:181500 |
|
| ORPHA:567 |
|
| OMIM:167870 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 103183994 | CALMI28692 | ||
| 102363275 | LATCH17564 | ||
| 561372 | ZFIN:ZDB-GENE-050913-117 | DANRE42593 | |
| 565370 | ZFIN:ZDB-GENE-040724-164 | DANRE01869 | |
| 103025058 | ASTMX04013 | ||
| 108265311 | ICTPU30273 | ||
| 124625982 | ICTPU30274 | ||
| 113573090 | ELEEL08877 | ||
| 115150851 | SALTR33931 | ||
| 115168561 | SALTR76287 |
