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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
catechol-O-methyltransferase
Summary
- Gene Symbol
-
- COMT
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Catecholamine metabolism
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- Magnesium
- Metal-binding
- Methyltransferase
- Neurotransmitter degradation
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Schizophrenia
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P21964 |
|
| A0A140VJG8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to dopamine | ||
| response to toxic substance | ||
| cholesterol efflux | ||
| dopamine secretion |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| L-dopa O-methyltransferase activity |
|
|
| orcinol O-methyltransferase activity |
|
|
| protein binding | ||
| catechol O-methyltransferase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050158 | desquamative interstitial pneumonia | |
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0050427 | xeroderma pigmentosum | |
| DOID:0050453 | lissencephaly | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050741 | alcohol dependence | |
| DOID:0050742 | nicotine dependence | |
| DOID:0050771 | pheochromocytoma | |
| DOID:0050778 | Meckel syndrome | |
| DOID:0050848 | obstructive sleep apnea |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000582 | Upslanted palpebral fissure |
| HP:0000600 | Abnormality of the pharynx |
| HP:0000627 | Posterior embryotoxon |
| HP:0000648 | Optic atrophy |
| HP:0000670 | Carious teeth |
| HP:0000682 | Abnormal dental enamel morphology |
| HP:0000708 | Atypical behavior |
| HP:0000716 | Depression |
| HP:0000717 | Autism |
| HP:0000738 | Hallucinations |
| Disease ID | Disease Name |
|---|---|
| OMIM:181500 |
|
| ORPHA:567 |
|
| OMIM:167870 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 115557386 | GADMO10047 | ||
| 101166546 | ORYLA14318 | ||
| 100693237 | ORENI58284 | ||
| 115582661 | SPAAU41170 | ||
| 379402 | Xenbase:XB-GENE-17337181 | ||
| 779254 | Xenbase:XB-GENE-6252788 | ||
| 108707135 | Xenbase:XB-GENE-6486206 | ||
| 549111 | Xenbase:XB-GENE-948947 | ||
| 549911 | Xenbase:XB-GENE-5865481 | ||
| 101942054 | CHRPI08201 |
