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desmoglein 3

Summary

Gene Symbol

Dsg3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13512

PubChem

13512

Alliance of Genome Resources

MGI:99499

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Glycoprotein
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UFC6
O35902	130 kDa pemphigus vulgaris antigen homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
desmosome assembly	IMP	9701552
actin filament organization	ISS
cell adhesion	TAS	10949543
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
negative regulation of cell migration	IMP	26763450

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

desmosome assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

desmosome assembly

cell-cell junction organization [inference]

desmosome organization [inference]

desmosome assembly

cell-cell junction assembly [inference]

desmosome assembly

supramolecular fiber organization [inference]

actin filament organization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

regulation of protein localization to adherens junction [inference]

positive regulation of protein localization to adherens junction

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of bicellular tight junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of cell junction assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of bicellular tight junction assembly [inference]

positive regulation of bicellular tight junction assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

regulation of protein localization to adherens junction [inference]

positive regulation of protein localization to adherens junction

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to adherens junction

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

negative regulation of p38MAPK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of p38MAPK cascade

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISS
plasma membrane	TAS	10949543
plasma membrane	IDA	9701552
adherens junction	ISS
spot adherens junction	TAS	10949543

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

spot adherens junction

desmosome

tight junction

bicellular tight junction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium ion binding	IBA
calcium ion binding	IEA
protein binding	IPI	18343367 26763450
protein dimerization activity	IDA	30949721

GO Hierarchy

molecular function

binding [inference]

protein binding

protein dimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Desmoglein-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 5** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like
Catenin binding domain superfamily
Desmosomal cadherin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060851	pemphigus vulgaris	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	1828	ZFIN:ZDB-GENE-091204-215
Danio rerio	1829	ZFIN:ZDB-GENE-091204-215
Homo sapiens	1830	ZFIN:ZDB-GENE-091204-215	HUMAN38009
Danio rerio	13510	ZFIN:ZDB-GENE-091204-215
Danio rerio	13511	ZFIN:ZDB-GENE-091204-215
Danio rerio	13512	ZFIN:ZDB-GENE-091204-215
Danio rerio	16769	ZFIN:ZDB-GENE-091204-215
Danio rerio	147409	ZFIN:ZDB-GENE-091204-215
Danio rerio	211924	ZFIN:ZDB-GENE-091204-215
Danio rerio	225256	ZFIN:ZDB-GENE-091204-215

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements