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ceruloplasmin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1356

PubChem

1356

Alliance of Genome Resources

HGNC:2295

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Glycoprotein
Ion transport
Metal-binding
Oxidoreductase
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P00450	Cuproxidase ceruloplasmin Ferroxidase ceruloplasmin Glutathione peroxidase ceruloplasmin Glutathione-dependent peroxiredoxin ceruloplasmin
A5PL27

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
iron ion transport
intracellular copper ion homeostasis	IDA	14623105
intracellular iron ion homeostasis	TAS
intracellular iron ion homeostasis	IDA	14623105
intracellular iron ion homeostasis	IMP	16150804 29183916

GO Hierarchy

biological process

cellular process [inference]

cellular detoxification [inference]

cellular oxidant detoxification

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

copper ion homeostasis [inference]

intracellular copper ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

copper ion homeostasis [inference]

intracellular copper ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

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GO Term	Evidence Code	PMID
extracellular region	NAS	14718574
extracellular region	TAS
extracellular space	IDA	16150804 19996109
extracellular space	HDA	16502470 20551380
lysosomal membrane	HDA	17897319

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

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GO Term	Evidence Code	PMID
ferroxidase activity	TAS
ferroxidase activity	IDA	14623105
ferroxidase activity	IMP	16150804 29183916
glutathione peroxidase activity	IDA	10481051 10508415
copper ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor

ferroxidase activity

binding [inference]

protein binding [inference]

protein-folding chaperone binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Laccase I

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
copper ion binding
metal ion binding
oxidoreductase activity

Displaying **all 7** entries
InterPro
Cupredoxin
Multicopper oxidase, C-terminal
Multicopper oxidase, copper-binding site
Multicopper oxidase, second cupredoxin domain
Multicopper oxidase-like, N-terminal
Multicopper oxidase
Multicopper oxidases, conserved site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050711	aceruloplasminemia	Alliance of Genome Resources
DOID:12119	hemosiderosis	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	1356	Xenbase:XB-GENE-6488817
Mus musculus	12870	ZFIN:ZDB-GENE-010522-1	MOUSE38427
Rattus norvegicus	24268		RATNO25637
Danio rerio	84702		DANRE22423
Sus scrofa	406870		PIGXX04911
Canis lupus familiaris	442963		CANLF09174
Ovis aries	443053		SHEEP01741
Pan troglodytes	460768		PANTR32413
Bos taurus	514194		BOVIN15191
Macaca mulatta	712210		MACMU29068

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements