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calcium voltage-gated channel auxiliary subunit gamma 4

Summary

Gene Symbol

Cacng4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

140725

PubChem

140725

Alliance of Genome Resources

RGD:628804

Annotation

Keyword

Calcium channel
Cell membrane
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HK86
Q8VHW9	Neuronal voltage-gated calcium channel gamma-4 subunit Transmembrane AMPAR regulatory protein gamma-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
transmission of nerve impulse	ISO
transmission of nerve impulse	IBA
response to cocaine	IDA	21276808
positive regulation of synaptic transmission, glutamatergic	IBA
calcium ion transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization

endosome to lysosome transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

transmission of nerve impulse

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to organic cyclic compound [inference]

response to cocaine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

response to salt [inference]

response to cocaine

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse [inference]

postsynaptic neurotransmitter receptor diffusion trapping

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

neurotransmitter receptor internalization

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization

endosome to lysosome transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

intracellular transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

protein transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

neurotransmitter receptor transport [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

neurotransmitter receptor transport, postsynaptic endosome to lysosome

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of postsynaptic neurotransmitter receptor activity

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of postsynaptic neurotransmitter receptor activity

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor diffusion trapping

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cell surface	IDA	21276808
AMPA glutamate receptor complex	ISO
AMPA glutamate receptor complex	IDA	19265014
AMPA glutamate receptor complex	IBA
somatodendritic compartment	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex [inference]

L-type voltage-gated calcium channel complex

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex [inference]

L-type voltage-gated calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex [inference]

L-type voltage-gated calcium channel complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
voltage-gated calcium channel activity	IBA
calcium channel regulator activity	ISS
calcium channel regulator activity	ISO
channel regulator activity	IBA
ionotropic glutamate receptor binding	IDA	12771129

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity

ion channel regulator activity [inference]

calcium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

voltage-dependent calcium channel

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
channel regulator activity
monoatomic ion transport
neurotransmitter receptor internalization
neurotransmitter receptor transport, postsynaptic endosome to lysosome
positive regulation of synaptic transmission, glutamatergic
postsynaptic neurotransmitter receptor diffusion trapping
transmission of nerve impulse

Displaying **all 2** entries
InterPro
PMP-22/EMP/MP20/Claudin
Voltage-dependent calcium channel, gamma subunit

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
postsynaptic density membrane	PMID:21276808
cell surface	PMID:21276808
cell body	PMID:23751177

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	10369	WB:WBGene00007670
Caenorhabditis elegans	12300	WB:WBGene00007670
Homo sapiens	27092	Xenbase:XB-GENE-1014199	HUMAN35792
Caenorhabditis elegans	54376	WB:WBGene00007670
Mus musculus	54377	Xenbase:XB-GENE-1014199	MOUSE06381
Caenorhabditis elegans	59283	WB:WBGene00007670
Caenorhabditis elegans	84347	WB:WBGene00007670
Xenopus tropicalis	140725	Xenbase:XB-GENE-1014199
Pan troglodytes	741406		PANTR15255
Danio rerio	794222		DANRE32158

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Acknowledgements