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SEC63 homolog, protein translocation regulator

Summary

Gene Symbol

Sec63

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

140740

PubChem

140740

Alliance of Genome Resources

MGI:2155302

Annotation

Keyword

Chaperone
Coiled coil
Endoplasmic reticulum
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8VHE0	DnaJ homolog subfamily C member 23

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nitrogen cycle metabolic process	IGI	21685914
post-translational protein targeting to membrane, translocation	ISO ISS
post-translational protein targeting to endoplasmic reticulum membrane	IBA IMP ISO	22375059
SRP-dependent cotranslational protein targeting to membrane	IBA IMP ISO	22375059
liver development	IGI IMP	21685914

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

nitrogen cycle metabolic process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

cotranslational protein targeting to membrane [inference]

SRP-dependent cotranslational protein targeting to membrane

post-translational protein targeting to endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	ISO	22375059
endoplasmic reticulum membrane	IEA
Sec62/Sec63 complex	IBA
endoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

Sec62/Sec63 complex

endoplasmic reticulum protein-containing complex [inference]

Sec62/Sec63 complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
protein transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

macromolecule transmembrane transporter activity [inference]

protein transmembrane transporter activity

protein transporter activity [inference]

protein transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

translocation protein SEC63 homolog

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
SRP-dependent cotranslational protein targeting to membrane
post-translational protein targeting to endoplasmic reticulum membrane

Displaying **all 5** entries
InterPro
C2 domain superfamily
Chaperone J-domain superfamily
DnaJ domain
Immunoglobulin E-set
Sec63 domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050770	polycystic liver disease	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **114** in total

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Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	11231		HGNC:21082	HUMAN85943
Drosophila melanogaster	38819		FB:FBgn0035771
Caenorhabditis elegans	173278		WB:WBGene00001047
Rattus norvegicus	309858	10116_1:0051cf	RGD:1304984	RATNO22002
Danio rerio	436861		ZFIN:ZDB-GENE-040718-328	DANRE18673
Pan troglodytes	462915			PANTR38805
Bos taurus	541040			BOVIN35585
Macaca mulatta	698863			MACMU35760
Saccharomyces cerevisiae S288C	854428		SGD:S000005780
Monodelphis domestica	100015912			MONDO12538

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OrthoDB (Group)

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Acknowledgements