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FMS-like tyrosine kinase 4

Summary

Gene Symbol

Flt4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14257

PubChem

14257

Alliance of Genome Resources

MGI:95561

Annotation

Keyword

ATP-binding
Angiogenesis
Cell membrane
Cytoplasm
Disulfide bond
Glycoprotein
Immunoglobulin domain
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35917	Fms-like tyrosine kinase 4 Tyrosine-protein kinase receptor FLT4
Q5SU94

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 56 in total

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GO Term	Evidence Code	PMID
angiogenesis
positive regulation of protein phosphorylation	ISO
positive regulation of endothelial cell proliferation	ISO
positive regulation of endothelial cell proliferation	IEA
vasculature development	IMP	9794766

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor-1 signaling pathway

cytokine-mediated signaling pathway [inference]

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

cell motility [inference]

cell migration

multicellular organismal process [inference]

system process [inference]

respiratory system process

respiratory gaseous exchange by respiratory system

developmental process [inference]

anatomical structure morphogenesis [inference]

lymphangiogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

sprouting angiogenesis

lymphangiogenesis

anatomical structure development [inference]

system development [inference]

vasculature development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to vascular endothelial growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to vascular endothelial growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of protein kinase C signaling [inference]

positive regulation of protein kinase C signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of protein kinase C signaling [inference]

positive regulation of protein kinase C signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of blood vessel remodeling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor-1 signaling pathway

cytokine-mediated signaling pathway [inference]

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of protein kinase C signaling [inference]

positive regulation of protein kinase C signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of protein kinase C signaling

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of tissue remodeling [inference]

regulation of blood vessel remodeling

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
nucleoplasm	ISO
cytoplasm	IEA
cytosol	ISO
plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase activity	ISO
GPI-linked ephrin receptor activity	IEA
transmembrane-ephrin receptor activity	IEA
epidermal growth factor receptor activity	IEA
fibroblast growth factor receptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

binding [inference]

protein binding

growth factor binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

collagen receptor activity [inference]

protein tyrosine kinase collagen receptor activity

neurotrophin receptor activity [inference]

brain-derived neurotrophic factor receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vascular endothelial growth factor

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

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Gene Ontology
ATP binding
angiogenesis
cell migration
endothelial cell differentiation
growth factor binding
metal ion binding
nucleotide binding
positive regulation of angiogenesis
positive regulation of cell migration
regulation of MAPK cascade

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InterPro
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, receptor class III, conserved site
VEGFR-2, transmembrane domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	1436	FB:FBgn0032006
Drosophila melanogaster	2321	FB:FBgn0032006
Drosophila melanogaster	2322	FB:FBgn0032006
Homo sapiens	2324	Xenbase:XB-GENE-483183	HUMAN82787
Drosophila melanogaster	3791	FB:FBgn0032006
Drosophila melanogaster	3815	FB:FBgn0032006
Caenorhabditis elegans	5156	WB:WBGene00006894
Caenorhabditis elegans	12978	WB:WBGene00006894
Drosophila melanogaster	14254	FB:FBgn0032006
Drosophila melanogaster	14255	FB:FBgn0032006

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements