GlyCosmos Portal

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GO Term	Evidence Code	PMID
protein tyrosine kinase activity	EXP	10037737 15962004 7999104 9398617
protein tyrosine kinase activity	IDA	10037737
transmembrane receptor protein tyrosine kinase activity	TAS	1417831
GPI-linked ephrin receptor activity	IEA
transmembrane-ephrin receptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

growth factor binding

vascular endothelial growth factor binding

heat shock protein binding [inference]

Hsp90 protein binding

identical protein binding

cell adhesion molecule binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

integrin binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

collagen receptor activity [inference]

protein tyrosine kinase collagen receptor activity

neurotrophin receptor activity [inference]

brain-derived neurotrophic factor receptor activity

coreceptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vascular endothelial growth factor receptor 2

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

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Gene Ontology
ATP binding
angiogenesis
cell migration
endothelial cell differentiation
growth factor binding
metal ion binding
nucleotide binding
positive regulation of angiogenesis
positive regulation of cell migration
regulation of MAPK cascade

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InterPro
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10873	Kuhnt-Junius degeneration	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:4448	macular degeneration	Alliance of Genome Resources
DOID:4511	breast angiosarcoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	1436	FB:FBgn0032006
Drosophila melanogaster	2321	FB:FBgn0032006
Drosophila melanogaster	2322	FB:FBgn0032006
Drosophila melanogaster	2324	FB:FBgn0032006
Xenopus tropicalis	3791	Xenbase:XB-GENE-6053213
Drosophila melanogaster	3815	FB:FBgn0032006
Caenorhabditis elegans	5156	WB:WBGene00006894
Caenorhabditis elegans	12978	WB:WBGene00006897
Drosophila melanogaster	14254	FB:FBgn0032006
Drosophila melanogaster	14255	FB:FBgn0032006

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Acknowledgements