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GlyTouCan
Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS raw data Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
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MIRAGE
Vascular endothelial growth factor receptor 2
Summary
- UniProt ID
- P35968
- Gene Symbol
-
- FLK1
- KDR
- VEGFR2
- Gene ID
- 3791
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Angiogenesis
- Cell junction
- Cell membrane
- Cytoplasm
- Cytoplasmic vesicle
- Developmental protein
- Differentiation
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Host-virus interaction
- Immunoglobulin domain
- Nucleus
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| membrane raft |
| extracellular region |
| nucleus |
| plasma membrane |
| cell junction |
| receptor complex |
| anchoring junction |
| endosome |
| early endosome |
| endoplasmic reticulum |
Sequence
MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 46 | N-linked (GlcNAc...) asparagine |
|
||
| 66 | N-linked (GlcNAc...) asparagine |
|
||
| 96 | N-linked (GlcNAc...) asparagine | |||
| 143 | N-linked (GlcNAc...) asparagine |
|
||
| 158 | N-linked (GlcNAc...) asparagine |
|
||
| 245 | N-linked (GlcNAc...) asparagine | |||
| 318 | N-linked (GlcNAc...) asparagine |
|
||
| 374 | N-linked (GlcNAc...) asparagine |
|
||
| 395 | N-linked (GlcNAc...) asparagine |
|
||
| 477 |
|
G27058EU
G80920RR
G62765YT
G59626AS
G01650EU
G31852PQ
G43417UB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | Homo sapiens |
| Integrin cell surface interactions | Homo sapiens |
| Neurophilin interactions with VEGF and VEGFR | Homo sapiens |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | Homo sapiens |
| VEGF binds to VEGFR leading to receptor dimerization | Homo sapiens |
| VEGFA-VEGFR2 Pathway | Homo sapiens |
| VEGFR2 mediated cell proliferation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:10534 | stomach cancer | |
| DOID:10763 | hypertension | |
| DOID:10873 | Kuhnt-Junius degeneration | |
| DOID:11054 | urinary bladder cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:3068 | glioblastoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:4448 | macular degeneration | |
| DOID:4511 | breast angiosarcoma |
