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cytochrome P450 family 2 subfamily C member 18

Summary

Gene Symbol

CYP2C18

Organism

Homo sapiens (human)

External Links

NCBI Gene

1562

PubChem

1562

Alliance of Genome Resources

HGNC:2620

Annotation

Keyword

3D-structure
Alternative splicing
Heme
Lipid metabolism
Membrane
Microsome
Monooxygenase
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q7Z348
P33260	CYPIIC18 Cytochrome P450-6b/29c

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
linoleic acid metabolic process	IEA
epoxygenase P450 pathway	IBA
xenobiotic metabolic process	IBA TAS
retinol metabolic process	IEA
retinoic acid metabolic process	IDA	11093772

GO Hierarchy

biological process

metabolic process [inference]

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

retinoic acid metabolic process

xenobiotic metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

retinoic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

retinoic acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

retinoic acid metabolic process

xenobiotic metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
intracellular membrane-bounded organelle	IBA IDA
plasma membrane	IDA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
aromatase activity	IEA
arachidonic acid epoxygenase activity	IBA
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA
oxygen binding	TAS	8110777
linoleic acid epoxygenase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

linoleic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

linoleic acid epoxygenase activity

binding [inference]

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CYTOCHROME P450

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181850	WB:WBGene00015043
Caenorhabditis elegans	181851	WB:WBGene00015044
Caenorhabditis elegans	181852	WB:WBGene00015045
Caenorhabditis elegans	182177	WB:WBGene00015400
Caenorhabditis elegans	183622	WB:WBGene00016786
Caenorhabditis elegans	189364	WB:WBGene00021168
Danio rerio	368352	ZFIN:ZDB-GENE-050522-490
Rattus norvegicus	499353	RGD:1563697
Xenopus tropicalis	548374	Xenbase:XB-GENE-5764740
Macaca mulatta	678686		MACMU45833