cytochrome P450 family 11 subfamily B member 2
| UniProt | Protein Name |
|---|---|
| P19099 |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of blood volume by renal aldosterone | ||
| renal water homeostasis | ||
| C21-steroid hormone biosynthetic process | ||
| glucocorticoid biosynthetic process | ||
| mineralocorticoid biosynthetic process |
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrion | ||
| mitochondrion | ||
| mitochondrial inner membrane | ||
| mitochondrial inner membrane | ||
| mitochondrial inner membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| steroid 11-beta-monooxygenase activity | ||
| steroid 11-beta-monooxygenase activity | ||
| steroid 11-beta-monooxygenase activity | ||
| iron ion binding | ||
| steroid hydroxylase activity |
| InterPro |
|---|
| Cytochrome P450 superfamily |
| Cytochrome P450, E-class, group I |
| Cytochrome P450, conserved site |
| Cytochrome P450 |
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080626 | corticosterone methyloxidase deficiency 1 | |
| DOID:0110429 | dilated cardiomyopathy 1H | |
| DOID:10591 | pre-eclampsia | |
| DOID:10763 | hypertension | |
| DOID:446 | primary hyperaldosteronism | |
| DOID:9351 | diabetes mellitus | |
| DOID:9352 | type 2 diabetes mellitus |
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000127 | Renal salt wasting |
| HP:0000360 | Tinnitus |
| HP:0000421 | Epistaxis |
| HP:0000811 | Abnormal external genitalia |
| HP:0000822 | Hypertension |
| HP:0000848 | Increased circulating renin level |
| HP:0001278 | Orthostatic hypotension |
| HP:0001290 | Generalized hypotonia |
| HP:0001324 | Muscle weakness |
| Disease ID | Disease Name |
|---|---|
| ORPHA:403 |
|
| OMIM:610600 |
|
| ORPHA:556030 |
|
| OMIM:203400 |
|
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100063612 | HORSE42961 | ||
| 100063645 | HORSE42957 | ||
| 100082065 | ORNAN20967 | ||
| 100415304 | CALJA13590 | ||
| 100415667 | CALJA13590 | ||
| 100461139 | PONAB34999 | ||
| 100478197 | AILME00805 | ||
| 100533461 | ORENI07604 | ||
| 100605657 | NOMLE40225 | ||
| 100654178 | LOXAF01708 |
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
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Last updated: December 8, 2025