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cytochrome P450 family 27 subfamily B member 1

Summary

Gene Symbol

CYP27B1

Aliases

1alpha(OH)ase
25-Hydroxyvitamin D3 1alpha-hydroxylase
CYP1
Calcidiol 1-monooxygenase
P450c1
VDDR I

Organism

Homo sapiens (human)

External Links

NCBI Gene

1594

HGNC

2606

KEGG Gene ID

hsa:1594

PubChem

1594

Alliance of Genome Resources

HGNC:2606

Annotation

Keyword

Disease variant
Heme
Lipid metabolism
Membrane
Mitochondrion
Monooxygenase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
O15528	25-OHD-1 alpha-hydroxylase 25-hydroxyvitamin D(3) 1-alpha-hydroxylase Calcidiol 1-monooxygenase Cytochrome P450 subfamily XXVIIB polypeptide 1 Cytochrome P450C1 alpha Cytochrome P450VD1-alpha Cytochrome p450 27B1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
vitamin metabolic process	TAS
calcium ion transport	ISS
negative regulation of cell population proliferation	IDA	16549446
negative regulation of calcidiol 1-monooxygenase activity	IDA	16549446
positive regulation of vitamin D 24-hydroxylase activity	IDA	16549446

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin metabolic process

fat-soluble vitamin metabolic process [inference]

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process [inference]

vitamin D catabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic hydroxy compound catabolic process [inference]

vitamin D catabolic process

organic hydroxy compound biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

cellular process [inference]

cell cycle process [inference]

G1 to G0 transition

cellular metabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

decidualization

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to estrogen

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to cytokine [inference]

response to type II interferon

response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of small molecule metabolic process [inference]

regulation of vitamin metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of alcohol biosynthetic process [inference]

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of small molecule metabolic process [inference]

negative regulation of vitamin metabolic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of alcohol biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of response to extracellular stimulus [inference]

regulation of response to nutrient levels [inference]

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of vitamin D receptor signaling pathway [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of vitamin D biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vitamin D receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of vitamin D biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

negative regulation of hormone metabolic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of hormone biosynthetic process [inference]

negative regulation of hormone biosynthetic process [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

regulation of vitamin D 24-hydroxylase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

regulation of calcidiol 1-monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of vitamin D 24-hydroxylase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of calcidiol 1-monooxygenase activity

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GO Term	Evidence Code	PMID
cytoplasm	IDA	15589699 16720713
mitochondrion	ISS
mitochondrion	TAS	9333115
mitochondrion	IBA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

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GO Term	Evidence Code	PMID
calcidiol 1-monooxygenase activity	TAS
calcidiol 1-monooxygenase activity	IDA	15795327 16549446 17023519 22862690 9415400
calcidiol 1-monooxygenase activity	IBA
iron ion binding	IEA
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

secalciferol 1-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

calcidiol 1-monooxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K07438

Name

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]

References

Rhea

RHEA:20573

H⁺ + O₂ + calcidiol

H₂O + calcitriol

Enzyme

1.14.15.18

PMID

RHEA:49064

H⁺ + O₂ + secalciferol

H₂O + calcitetrol

Enzyme

1.14.15.18

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080886	vitamin D-dependent rickets type 1A	Alliance of Genome Resources
DOID:10609	rickets	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **21 - 30** of 60 in total

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HPO ID	HPO Term
HP:0002007	Frontal bossing
HP:0002148	Hypophosphatemia
HP:0002199	Hypocalcemic seizures
HP:0002240	Hepatomegaly
HP:0002355	Difficulty walking
HP:0002653	Bone pain
HP:0002659	Increased susceptibility to fractures
HP:0002663	Delayed epiphyseal ossification
HP:0002748	Rickets
HP:0002749	Osteomalacia

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:264700	vitamin D-dependent rickets, type 1A
ORPHA:289157	vitamin D-dependent rickets, type 1

PubChem Disease

GHR Health Conditions

MedGen Diseases

Vitamin D-dependent rickets, type 1A

OMIM Phenotypes

VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A; VDDR1A

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000490
Gene Name: cytochrome P450, family 27, subfamily B, polypeptide 1

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	1591	FB:FBgn0036806
Drosophila melanogaster	1593	FB:FBgn0033753
Xenopus tropicalis	1594	Xenbase:XB-GENE-490214
Mus musculus	13115		MOUSE00710
Xenopus tropicalis	53342	Xenbase:XB-GENE-490214
Rattus norvegicus	114700		RATNO37965
Sus scrofa	397055		PIGXX25705
Pan troglodytes	452027		PANTR05438
Canis lupus familiaris	481133		CANLF01363
Bos taurus	539630		BOVIN29534

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements