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MIRAGE
angiotensin I converting enzyme
Summary
- Gene Symbol
-
- ACE
- Aliases
-
- ACE1
- CD143
- peptidyl-dipeptidase A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative promoter usage
- Alternative splicing
- Calmodulin-binding
- Carboxypeptidase
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Zinc
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of systemic arterial blood pressure by renin-angiotensin | ||
| regulation of systemic arterial blood pressure by renin-angiotensin | ||
| positive regulation of systemic arterial blood pressure | ||
| proteolysis | ||
| spermatogenesis |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of localization [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| actin binding | ||
| endopeptidase activity | ||
| carboxypeptidase activity |
|
|
| metallocarboxypeptidase activity | ||
| metalloendopeptidase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- angiotensin-converting enzyme
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| carboxypeptidase activity |
| hydrolase activity |
| metal ion binding |
| metallopeptidase activity |
| peptidyl-dipeptidase activity |
| proteolysis |
| InterPro |
|---|
| Peptidase M2, peptidyl-dipeptidase A |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050152 | aspiration pneumonia | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0050864 | non-arteritic anterior ischemic optic neuropathy | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0080599 | Coronavirus infectious disease | |
| DOID:0080600 | COVID-19 | |
| DOID:10534 | stomach cancer | |
| DOID:10591 | pre-eclampsia | |
| DOID:10763 | hypertension | |
| DOID:10952 | nephritis |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000079 | Abnormality of the urinary system |
| HP:0000252 | Microcephaly |
| HP:0001562 | Oligohydramnios |
| HP:0002009 | Potter facies |
| HP:0002089 | Pulmonary hypoplasia |
| HP:0002093 | Respiratory insufficiency |
| HP:0002615 | Hypotension |
| HP:0004492 | Widely patent fontanelles and sutures |
| HP:0008660 | Renotubular dysgenesis |
| Disease ID | Disease Name |
|---|---|
| OMIM:267430 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100453403 | PONAB11851 | ||
| 100464084 | AILME09933 | ||
| 100558092 | ANOCA08382 | ||
| 100667696 | LOXAF10287 | ||
| 100712518 | ORENI72037 | ||
| 100715217 | CAVPO18789 | ||
| 100932537 | SARHA13385 | ||
| 100946178 | OTOGA14886 | ||
| 101020307 | PAPAN13845 | ||
| 101076790 | TAKRU23384 |
