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MIRAGE
angiotensin I converting enzyme
Summary
- Gene Symbol
-
- ACE
- Aliases
-
- ACE1
- CD143
- peptidyl-dipeptidase A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative promoter usage
- Alternative splicing
- Calmodulin-binding
- Carboxypeptidase
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Zinc
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| post-transcriptional regulation of gene expression | ||
| posttranscriptional regulation of gene expression | ||
| negative regulation of gene expression | ||
| substance P catabolic process | ||
| bradykinin catabolic process |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of localization [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| actin binding | ||
| endopeptidase activity | ||
| carboxypeptidase activity |
|
|
| metallocarboxypeptidase activity | ||
| metalloendopeptidase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- angiotensin-converting enzyme
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| carboxypeptidase activity |
| hydrolase activity |
| metal ion binding |
| metallopeptidase activity |
| peptidyl-dipeptidase activity |
| proteolysis |
| InterPro |
|---|
| Peptidase M2, peptidyl-dipeptidase A |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:552 | pneumonia | |
| DOID:576 | proteinuria | |
| DOID:5844 | myocardial infarction | |
| DOID:61 | mitral valve disease | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:7147 | ankylosing spondylitis | |
| DOID:783 | end stage renal disease | |
| DOID:8432 | polycythemia | |
| DOID:8947 | diabetic retinopathy | |
| DOID:8970 | subacute sclerosing panencephalitis |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000079 | Abnormality of the urinary system |
| HP:0000252 | Microcephaly |
| HP:0001562 | Oligohydramnios |
| HP:0002009 | Potter facies |
| HP:0002089 | Pulmonary hypoplasia |
| HP:0002093 | Respiratory insufficiency |
| HP:0002615 | Hypotension |
| HP:0004492 | Widely patent fontanelles and sutures |
| HP:0008660 | Renotubular dysgenesis |
| Disease ID | Disease Name |
|---|---|
| OMIM:267430 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1636 | Xenbase:XB-GENE-479789 | ||
| 11421 | Xenbase:XB-GENE-479789 | MOUSE05963 | |
| 24310 | Xenbase:XB-GENE-479789 | RATNO01757 | |
| 34189 | Xenbase:XB-GENE-479789 | ||
| 34805 | Xenbase:XB-GENE-479789 | ||
| 34808 | WB:WBGene00000039 | ||
| 59272 | WB:WBGene00000039 | ||
| 70008 | WB:WBGene00000039 | ||
| 180780 | ZFIN:ZDB-GENE-030131-1826 | ||
| 217246 | Xenbase:XB-GENE-479789 |
