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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
aldo-keto reductase family 1 member C1
Summary
- Gene Symbol
-
- AKR1C1
- Aliases
-
- DD1
- DDH
- HAKRC
- MBAB
- dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- NADP
- Oxidoreductase
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| Q04828 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| intestinal cholesterol absorption |
|
|
| retinal metabolic process | ||
| cholesterol homeostasis |
|
|
| retinoid metabolic process |
|
|
| digestion |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| testosterone 17-beta-dehydrogenase (NADP+) activity | ||
| aldo-keto reductase (NADP) activity |
|
|
| steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
|
|
| ketosteroid monooxygenase activity | ||
| bile acid binding |
GO Hierarchy
- estradiol 17-beta-dehydrogenase [NAD(P)] activity
- testosterone dehydrogenase [NAD(P)] activity
- dihydrotestosterone 17-beta-dehydrogenase activity
- 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- 3beta-hydroxy-5beta-steroid dehydrogenase activity
- estradiol 17-beta-dehydrogenase [NAD(P)] activity
- testosterone dehydrogenase [NAD(P)] activity
- dihydrotestosterone 17-beta-dehydrogenase activity
- 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- indanol dehydrogenase activity
molecular function
catalytic activity [inference]
oxidoreductase activity [inference]
steroid dehydrogenase activity [inference]
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity, acting on CH-OH group of donors [inference]
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:2187 | amelogenesis imperfecta | |
| DOID:219 | colon cancer | |
| DOID:235 | colonic benign neoplasm | |
| DOID:2394 | ovarian cancer | |
| DOID:2571 | Langerhans-cell histiocytosis | |
| DOID:2645 | benign mesothelioma | |
| DOID:2871 | endometrial carcinoma | |
| DOID:288 | endometriosis of uterus | |
| DOID:289 | endometriosis | |
| DOID:2994 | germ cell cancer |
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP002152
- Gene Name
- aldo-keto reductase family 1, member C1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 711198 | MACMU44830 | ||
| 711440 | MACMU44830 | ||
| 101146324 | GORGO01592 | ||
| 115936027 | GORGO01592 | ||
| 100171658 | PONAB00765 | ||
| 100189776 | PONAB00776 | ||
| 70861 | MGI:1918111 | ||
| 77337 | MGI:1924587 | ||
| 83702 | MGI:1933427 | ||
| 105387 | MGI:2145458 |
